Sporting defender Luis Neto will take Pepe's place in coach Fernando Santos' squad, the FPF said in a statement on Sunday evening.
Premier League: Diogo Jota returns to haunt former club Wolves as Liverpool win to claim 'three dirty points'
Victory moved the English champions back up to sixth and within five points of fourth-placed Chelsea.
Premier League: Pedro Neto's second-half stunner sees Wolves complete comeback win against Southampton
Nuno Espirito Santo was able to celebrate in his 100th Premier League game as Wolves boss thanks to their spirited second-half fightback at St Mary's.
Premier League: Mason Mount helps Chelsea end barren run against Fulham; Leicester go second after beating Southampton
Mason Mount put Chelsea back on track with the late winner that sealed a vital 1-0 victory at 10-man Fulham.
Sporting Lisbon's ex-president acquitted of inciting attack on players as Portuguese court sentences nine
In May 2018 a group of hooded Sporting fans armed with sticks and belts attacked players at the club’s training ground after the team failed to qualify for the Champions League.
Premier League: Manchester United boss Ole Gunnar Solskjaer refuses to blame Paul Pogba after penalty miss
Ole Gunnar Solskjaer refused to blame Paul Pogba after the Manchester United star missed a penalty in Monday's 1-1 draw at Wolves after taking spot-kick duties from Marcus Rashford.
Premier League: Wolves hold Manchester United after Rui Patricio saves Paul Pogba's second-half penalty
Manchester United were forced to settle for a 1-1 draw against Wolves after Paul Pogba's penalty was saved by Rui Patricio at Molineux on Monday.
Goalkeeper Rui Patricio turns hero as Wolves beat Manchester City in penalties to clinch Premier League Asia Trophy
Goalkeeper Rui Patricio was the hero for Wolves, saving three spot-kicks after their Asia Trophy final against Manchester City went to penalties on Saturday in Shanghai.
Premier League: Wolverhampton Wanderers sign Belgian international Leander Dendoncker from Anderlecht
Wolves' impressive recruitment ahead of their return to the Premier League for the first time in seven years continued on Thursday with the signing of Belgian international Leander Dendoncker
Edinson Cavani scored twice as Uruguay shattered Cristiano Ronaldo's World Cup dream with a 2-1 victory over Portugal on Saturday
FIFA World Cup 2018: Portugal finish second in Group B after conceding controversial injury-time penalty against Iran
Ricardo Quaresma curled in a trademark trivela goal but Karim Ansarifard's late penalty dropped Portugal to second in Group B behind neighbours Spain.
Three Portugal stars currently in Russia getting ready for the World Cup have told their club Sporting Portugal they will break their contracts, the club said on Monday.
FIFA World Cup 2018: From in-form Alisson Becker to Manuel Neuer's much-awaited comeback, top goalkeepers to watch out for
From in-form Alisson Becker to Manuel Neuer's much-awaited comeback, here's a list of top goalkeepers to watch out for at the FIFA World Cup 2018 in Russia.
Cristiano Ronaldo was surprisingly left out of the Portugal squad announced on Friday by coach Fernando Santos, who suggested it was merely to give his superstar a break.
European champions Portugal won 2-1 courtesy of goals from centre-back Pepe and substitute Adrien Silva's penalty in extra-time.
Confederations Cup 2017: Portugal held by Mexico in opening game after Hector Moreno's stoppage-time goal
Portugal conceded a late equaliser in a 2-2 draw with Mexico at the Confederations Cup on Sunday. Ronaldo set-up the first goal and hit the bar once in a display that got him the player of the match award
UEFA on Monday announced team of the tournament and named tournament top scorer Antoine Griezmann as the best player of Euro 2016.
Portugal beat hosts France 1-0 in the Euro 2016 final on Sunday night thanks to substitute Eder's dramatic strike in extra-time at the Stade de France
Pragmatic Portugal with their impervious defence emerged surprising winners on a night that was high on drama, but will not be remembered for the football it produced.
Few would have predicted Portugal to make the Euro 2016 finals after their opening 1-1 draw against Iceland, but here they are.