Tsitsipas, who was coming off semi-final appearances at the Australian Open and Rotterdam, was denied a sixth ATP trophy.
Mexican Open: Alexander Zverev battles past Dominik Koepfer, earthquake to set up final with Stefanos Tsitsipas
Zverev was shaken but not unnerved by an earthquake in the second set of his 6-4, 7-6 (7/5) victory over fellow German Dominik Koepfer.
Mexican Open: Nick Kyrgios slams Acapulco crowd for 'disrespect' after being jeered in injury-forced first round exit
Nick Kyrgios has accused the Mexican Open crowd of “disrespect” after being jeered following his retirement against Frenchman Ugo Humbert due to a left wrist injury.
Mexican Open: Rafael Nadal says Acapulco 'feels like home', recounts title wins in 2005 and 2013 as key moments in his career
Nadal has won the title or reached the final in three of his four appearances and views his 2013 win as a key moment in his career
Tennis Rankings: Roger Federer rises to fourth with 100th title win; Wang Yafan breaks into WTA top-50
Novak Djokovic took the week off but remains a long way clear at the top, though the likes of Nadal, Federer and Zverev gained a handful of points in Dubai and Mexico
Mexican Open: Nick Kyrgios’ headline-grabbing show earns him another title along with renewed respect of tennis world
By defeating Alexander Zverev in straight sets in the final, Nick Kyrgios has proven yet again that when he's on his game, he's capable of defeating anyone.
After Wang held at love to 5-5, she reeled off the last four points of the 11th game to break Kenin and then held serve for the triumph
Mexican Open: Nick Kyrgios continues fine run to set up title clash with Alexander Zverev; Wang Yafan to face Sofia Kenin in final
Nick Kyrgios continued his scintillating run at the Mexican Open by downing John Isner in three sets to book a title showdown with Alexander Zverev.
German youngster Alexander Zverev has 10 ATP Tour titles, winning five times in 2017 and four last year, and he is widely considered to be one of the best talents in the sports
Mexican Open: Nick Kyrgios turns deaf ear to accusations from Rafael Nadal criticizing Australian of 'lacking respect'
The quick-playing Kyrgios tried an underarm serve late on in the encounter in an effort to catch Nadal off guard, after the 17-times grand slam champion had moved far behind the baseline to receive
Uncharacteristic Nick Kyrgios pulls victory from jaws of defeat to stun World No 2 Rafael Nadal at Mexican Open
Nick Kyrgios has frequently tanked — or at the very least come close to tanking — matches, struggled with form, fitness, and commitment to the game. But in Thursday’s match, he gave a performance that he could watch when lacking motivation.
Nick Kyrgios leveled his head-to-head record with Rafael Nadal at 3-3 and will play three-time Grand Slam champion Stan Wawrinka for a place in the semi-finals
Seeing del Potro lift his first ATP Masters 1000 trophy boosted his excitable legion of fans who feared he would never be able to mix it with the very best after a succession of injury setbacks almost forced him into retirement.
Nishikori withdrew from the Australian Open with a wrist injury and in his most recent outing at the Mexican Open, he lost in the first round to Denis Shapovalov.
Indian Wells Masters: World No 1 Roger Federer looks to defend title and win unprecedented sixth crown
Federer has enjoyed a perfect start to 2018 by winning both events he has competed in and taking his career singles title tally to 97.
Mexican Open: Juan Martin del Potro beats Kevin Anderson to clinch ATP title; Lesia Tsurenko defends WTA trophy
Juan Martin del Potro won the Mexico Open for his 21st ATP Tour title, beating Kevin Anderson 6-4, 6-4. Lesia Tsurenko successfully defended the women's title with a 5-7, 7-6 (2), 6-2 victory over Stefanie Voegele.
Mexican Open: Juan Martin del Potro sets up title clash against Kevin Anderson; reigning champ Lesia Tsurenko into final
Juan Martin del Potro dispatched top seed Alexander Zverev 6-4, 6-2 in the semi-final of the Mexican Open to set up a decider against Kevin Anderson.
After withdrawing from Basel, Paris, ATP Tour Finals, Brisbane, Australian Open and Acapulco, Nadal has now pulled out of this month's events in Miami and Indian Wells
Mexican Open: Top-seed Sloane Stephens downs Arantxa Rus; Dominic Thiem beats Denis Shapovalov to enter quarters
Stephens won the US Open last year for her first Grand Slam title and took the Acapulco hardcourt event in 2016.
Mexican Open: Nick Kyrgios bemoans lack of action taken against Daria Gavrilova following her temper tantrum
American Coco Vandeweghe, who has also found herself in trouble with tennis authorities, appeared to support Kyrgios with a reply to his tweet.