Andy Murray, who is on the comeback trail after hip surgery two years ago, won the Miami Open in 2009 and 2013 and reached the final of the event in 2012 and 2015.
Kim Clijsters only played three tournaments and three matches in 2020, beaten each time in the first round.
Clijsters' comeback was disrupted by the coronavirus pandemic and she has yet to play in 2021. Miami will mark her first event since her first-round loss in the US Open in September.
'Nerveless performance, first of many': Twitter reacts to Iga Swiatek's first-ever Grand Slam win at French Open 2020
Here's how twitter reacted to Polish tennis star Iga Swiatek's straight sets win over Sofia Kenin in the French Open 2020 final!
US Open 2020: Venus Williams suffers first-ever opening round exit in New York, Kim Clijsters' comeback foiled
Venus Williams was beaten in the first round for the first time in her glittering career by Karolina Muchova.
US Open 2020: Andy Murray secures win after thrilling fightback; Serena Williams, Dominic Thiem progress to second round
Andy Murray fought back from two sets down to win a five-set thriller against Japan's Yoshihito Nishioka, in his first singles Grand Slam match in 18 months because of injury and the coronavirus pandemic.
US Open 2020: Setback for Kim Clijsters after she pulls out of Western and Southern Open due to abdominal injury
The 37-year-old Clijsters came out of retirement this year and the US Open will be her first Grand Slam tournament since she competed at Flushing Meadows in 2012.
The Bryans, Bob and Mike, won five of their 16 Grand Slam doubles titles together in New York, most recently in 2014.
US Open 2020: Former champions Andy Murray, Kim Clijsters receive wild card entry for upcoming Grand Slam
Former world number one Murray, currently ranked 129 after a lengthy period battling a hip injury, narrowly missed direct entry.
Kim Clijsters, Sloane Stephens headline World TeamTennis as season kicks off with safety measures in place
The tennis tournament takes place weeks after the Adria Tour was cancelled following its second leg in Croatia due to numerous positive coronavirus tests among participants, including Novak Djokovic, the top-ranked player in the world.
Former world number one Clijsters and 2017 US Open champion Sloane Stephens are among the headliners as World TeamTennis (WTT) kicks off its three-week regular season on Sunday
World TeamTennis changes COVID-19 policies including prorated pay for players testing positive during tournament
Full salaries will be paid to tennis players who get sick during the three-week season.
Someone testing positive once World TeamTennis has started would be held out for the rest of the season but still be compensated on a prorated basis.
Belgian mother-of-three Clijsters surprised the tennis world when she announced she was making a second comeback this year.
In alternate universe: Rafael Nadal begins chase for 20th Grand Slam title at Roland Garros, Serena Williams her 24th
With Roland Garros rescheduled, players and fans alike are left to merely think and talk about what might have been happening in Paris during the 15-day period that began Sunday and ends 7 June, the original date of the men's singles final at Court Philippe Chatrier
Monterrey Open: Trusting the process and improving every day is key to success, says Kim Clijsters after loss to Johanna Konta
Clijsters, 36, had lost to Spain’s Garbine Muguruza in her first match since returning to the WTA Tour at the Dubai Duty-Free Tennis Championships last month
Mary Pierce interview: Pressures of fame difficult to handle for younger players like Naomi Osaka, says former Roland Garros champion
Former Roland Garros and Australian Open champion Mary Pierce touched base on wide range of topics such as level of women's tennis today, the unpredictability, rise of Coco Gauff and return of Kim Clijsters.
Dubai Tennis Championships: Kim Clijsters loses in straight sets against Garbine Muguruza on return to WTA Tour
Kim Clijsters' first WTA Tour match since 2012 ended with a 6-2, 7-6 (6) loss to Garbine Muguruza at the Dubai Championships.
Kim Clijsters' long awaited return to the tennis court happened in front of a sizeable crowd in Dubai against Garbine Muguruza and at times it looked like it was 2011.
Clijsters has been drawn against sixth seeded Kiki Bertens of the Netherlands after being given a wildcard entry