Fabio Quartararo News
Even better for Quartararo was neither of his Italian rivals who loom large in the championship standings finished.
The Yamaha rider dominated the race and finished more than five seconds ahead of fellow Frenchman Johann Zarco of Ducati-Pramac.
The 32-year-old also gave Aprilia a maiden triumph in the sport's premier class while he took over the lead of the world championship after three rounds.
The Portuguese KTM rider finished 2.205 sec ahead of current world champion Fabio Quartararo, of France, who had started from pole position on his Yamaha.
Italy's Bagnaia, who had started on pole position for a fifth consecutive race, finished ahead of 2020 world champion Joan Mir of Suzuki and Australia's Jack Miller, also on a Ducati.
Quartararo's win comes in his third season in MotoGP, the first with Yamaha's factory team after two years with the SRT satellite outfit. Of the 16 MotoGPs he has contested this season, he has claimed 10 podiums, including five victories.
Marquez, starting third on the grid, seized the lead at the start and relentlessly powered to victory over championship leader Fabio Quartararo of France.
The Italian, who celebrated his debut win in the premier category last weekend in Aragon, came under intense pressure from championship leader Fabio Quartararo in the closing laps.
Ducati rider Bagnaia, who won his first GP at Aragon last weekend, posted a blistering best time of one minute, 31.065 seconds at Misano, finishing ahead of teammate Jack Miller and championship leader Fabio Quartararo.
This was Bagnaia's debut success in the premier category after 10 wins combined in Moto2 and Moto3.
The 22-year-old French Yamaha rider hurt his left ankle when he slipped at turn eight at Silverstone.
After the Dutch GP at the end of June, it was announced that Maverick Vinales, who has already signed to ride for Aprilia next season, would cut short his contract and leave at the end of the season.
Unlike his rivals who pitted to change bikes, Binder opted to stay out on slick tyres and skillfully held off the field to win his second-ever MotoGP.
On the fastest track in MotoGP, championship leader Fabio Quartararo seemed to have sealed pole position when he smashed the record set last week by fellow Frenchman Johann Zarco last weekend ahead of the Styria Grand Prix.
French championship leader Fabio Quartararo of Yamaha was third in a race that had to be restarted after the KTM of Spaniard Dani Pedrosa and the Aprilia of Italian Lorenzo Savadori caught fire in the middle of the track following a crash.
Rossi told a press conference ahead of this weekend's Styrian Grand Prix that he will call it a day, 12 years on from his last MotoGP title.
Quartararo, 22, in just his third term at the top table of racing extended his advantage to 34 points ahead of second-placed Johann Zarco, who had to contend with a fourth place in the Netherlands.
MotoGP 2021: Maverick Vinales claims pole position at Dutch MotoGP, Marc Marquez to begin in 20th position
Vinales' French teammate and championship leader Fabio Quartararo was second, at 0.071sec, with Ducati's Italian rider Francesco Bagnaia in third (+0.302).
MotoGP 2021: Yamaha's Maverick Vinales sets quickest time in third practice ahead of Dutch MotoGP qualifying
The Spaniard had been fastest in both of Friday's sessions and went on to clock a leading 1min 32.336 sec in the third run-out in dry conditions.
MotoGP 2021: Maverick Vinales sets fastest time in Dutch MotoGP first practice as Marc Marquez crashes
Spaniard Vinales was fastest in both sessions, recording 1min 33.072sec in the dry morning conditions and then 1:33.241 on a rainy afternoon.