Federer, who will turn 40 in August, has played just one tournament in 2021, winning one match in Qatar in March on his return from 13 months on the sidelines after undergoing two bouts of knee surgeries.
Monte Carlo Masters: Rafael Nadal 'not worried' about COVID-19 infection after Daniil Medvedev practice
Nadal was not considered a close contact of Medvedev, and therefore not required to quarantine, allowing him to pursue a 12th Monte Carlo title.
Monte Carlo Masters: Stefanos Tsitsipas strolls into last-16; Novak Djokovic to face rising star Jannik Sinner
Tsitsipas, who had been given a bye into the second round, took just one hour and 24 minutes to beat 29th-ranked Russian Karatsev.
Rafa Nadal is aiming for a 12th Masters title in the principality ahead of his pursuit of a 14th French Open success and a record 21st Grand Slam.
"It's been a long and tough road for me," said Federer, who hasn't played a match since a semis defeat to Novak Djokovic at the Australian Open in January 2020, 405 days ago.
Federer hasn't played a match since his semis loss to Novak Djokovic at the Australian Open in January 2020 and joked with the umpire about the rules of the game at the start of his game against Dan Evans at Doha.
The defeat left Medvedev, 25, a leading member of the next generation, wondering how to overcome Djokovic, Rafael Nadal and Roger Federer, who have 58 major titles between them.
A strict vegetarian diet, spiritual guru and family hugging-sessions are among the unusual methods that have helped Novak Djokovic to take his place among the immortals of tennis.
Here's a look at Djokovic's incredible run of success and the records he has set on the way to becoming the undoubted king of Melbourne Park:
Novak Djokovic’s Australian Open dominance improved to 18-0 combined in semi-finals and finals. On Sunday, Daniil Medvedev joined the ranks of Roger Federer, Rafael Nadal, Andy Murray, Stan Wawrinka, Dominic Thiem, all of whom have lost to Djoko in semis or finals in Melbourne.
After beating qualifier Aslan Karatsev, Djokovic, showing no ill-effects from an abdomen injury sustained in the third round, said, "This is the best I've felt in the entire tournament. I could swing through the ball. No pain. The best match so far."
"I wasn't thinking about a lot of things," said Tsitsipas. "How would I describe myself? Nirvana. Just was there... playing, not thinking."
"I'm not the guy that's going to find excuses on that or going to complain about what happened, no. Just accept. I never considered myself an unlucky person at all," Rafael Nadal said after his ouster.
Australian Open 2021: For some, facing a Grand Slam legend means a dream come true. And a lopsided defeat
It is a tricky balance when someone of Cameron Norrie’s ilk — ranked 69th and, until this week, the owner of a grand total of six wins in Grand Slam matches — goes up against someone of Rafa Nadal’s stature on one of their sport’s biggest stages.
Australian Open 2021: Rafael Nadal emerges unscathed from 'tough' workout to keep Grand Slam dream alive
World No 2 Rafael Nadal accelerated his pursuit of a record 21st Grand Slam title on Saturday with a testing victory over Cameron Norrie.
The lines for beer on Day 1 at the Australian Open were noticeably thinner than usual, and the lawn chairs set up in front of the giant television screen in Garden Square were far emptier.
'When you play in front of an empty big stadium, it just feels very strange,' said Novak Djokovic
Australian Open: Rafael Nadal says he's 'still not ready' as star reveals he'll sit out ATP Cup clash against Greece
The Australian Open gets underway on Monday with Nadal, the 2009 champion, looking to edge ahead of Roger Federer, who also has 20 Slam titles to his name.
ATP Finals 2020: Dominic Thiem secures victory over Rafael Nadal; Stefanos Tsitsipas outlasts Andrey Rublev
Nadal, who lost the 2010 and 2013 finals of the event, has to beat Tsitsipas in his last group match to reach the semi-finals of the prestigious season-ending tournament.
Rafael Nadal has never won the Paris Masters in his career. This year, the tournament is scheduled to run from 2-8 November.