Medvedev was on top form in a high-quality encounter, winning 5-7, 6-4, 6-1 to secure his first trophy of the season and the eighth of his career.
Paris Masters 2020: Alexander Zverev beats Rafael Nadal in straight sets to set up final against Daniil Medvedev
The German claimed his second successive win over Nadal in impressive fashion, easing to a 6-4, 7-5 victory after Medvedev's earlier 6-4, 7-6 (7/4) win over Milos Raonic.
Nadal, who claimed his 1,000th career victory by beating Feliciano Lopez on Wednesday, is bidding for a first Paris indoors triumph which would draw him level with Novak Djokovic on a record 36 Masters titles.
Paris Masters 2020: Rafael Nadal romps to 1000 Tour-level wins; Diego Schwartzman inches closer to ATP Finals debut
The 28-year-old Schwartzman was too strong for France's Gasquet, taking a 7-5, 6-3 victory, and will next face Spanish qualifier Alejandro Davidovich Fokina in the last 16 at Bercy Arena.
Humbert, who is on a seven-match winning streak after winning the Antwerp title last month, missed four match points but battled to a 7-6 (7/4), 6-7 (6/8), 7-6 (7/3) victory.
Wawrinka won the last of his three Grand Slam titles at the 2016 US Open but was then hit by multiple injuries and is now ranked 20th in the world.
Italian Open 2020: After US Open run, Shapovalov piling up wins in Rome, Azarenka double bagels Kenin
After spending more than 22 hours on court over the previous two weeks at the US Open, where he reached the quarterfinals in both singles and doubles, Shapovalov is still going strong after crossing the Atlantic.
Italian Open 2020: Teenager Lorenzo Musetti stuns Stan Wawrinka; Garbine Muguruza beats Sloane Stephens in straight sets
Stan Wawrinka, the 10th seed in Rome, lost 6-0, 7-6 (7/2) against a player ranked 249th in the world.
US Open 2020 Men's Preview: Novak Djokovic's title to lose; potential first-time winners abound in draw
Novak Djokovic is the overwhelming favourite to win the US Open, which starts on 31 August, with multiple players hopeful of lifting their first Grand Slam trophy.
Western & Southern Open: Novak Djokovic clinches record-equalling 35th Masters title by beating Milos Raonic
Novak Djokovic tied Rafael Nadal’s record by earning his 35th title at a Masters 1000 tournament, overcoming a sluggish start to beat Milos Raonic in the Western & Southern Open final.
Among the areas the PTPA would look into, according to the email: ATP and tournament rules and regulations, revenue sharing, disciplinary actions, pensions, travel, on-site food and amenities, insurance and medical care.
Western & Southern Open: Naomi Osaka withdraws from semi-final in protest, tournament 'paused' for a day
Naomi Osaka tweeted that as a Black woman, she feels compelled to pull out of the tournament to put a focus on police shooting Black people.
Western & Southern Open: Serena Williams stunned by Maria Sakkari; Novak Djokovic reaches QF with commanding win
Novak Djokovic’s neck felt much better, and his tennis looked much better, in a 6-2, 6-4 victory over unseeded American Tennys Sandgren at the Western & Southern Open on Tuesday that improved the No. 1-ranked man to 20-0 in 2020.
Australian Open 2020: Novak Djokovic thumps Milos Raonic in straight sets to confirm semi-final showdown with Roger Federer
Federer beat the biceps-baring, hard-hitting, court-covering Sandgren 6-3, 2-6, 2-6, 7-6 (8), 6-3 on Tuesday in a rollicking quarter-final that appeared to be over long before it truly was.
On Sunday morning, Raonic continued with his devastating serving form during a 6-4, 6-3, 7-5 victory over former finalist Cilic. Next up: Novak Djokovic.
Australian Open 2020: Roger Federer beats Marton Fucsovics in fourth round to set up QF clash with Tennys Sandgren
The third-seeded Federer will now face American Tennys Sandgren, who defeated No. 12 seed Fabio Fognini 7-6(5) 7-5 6-7(2) 6-4 earlier on Sunday.
Milos Raonic has always been a great server. But what he did on Friday against Stefanos Tsitsipas at the Australian Open was special even by his standards.
Australian Open 2020: Milos Raonic ends Stefanos Tsitsipas' campaign with straight sets win over Greek in third round
Raonic, who reached the last four at Melbourne Park in 2016 and the Wimbledon final the same year, hit 19 aces and 55 winners and did not give ATP Finals champion Tsitsipas a single breakpoint opportunity in the match.
Australian Open 2020: Roger Federer cruises into third round; Fabio Fognini emerges victorious after marathon five-setter
Checkout all the match results of the men's singles fixtures from the third day of the Australian Open 2020.
Australian Open 2020: World No 39 Marin Cilic says 'intent in practice' and 'right mindset' key after winning first-round match
Cilic looked a lot more confident on the court in his first outing at the Australian Open than he did at any point last year