Popyrin started off badly, losing the first set 4-6 but charged back and snatched the second 6-0.
Mannarino, who had beaten Albot in their only previous encounter in Sofia last year, could not repeat that feat again as the Moldovan was clearly at his best.
Bengaluru Open 2020: Leander Paes-Matthew Ebden lose in final at Indian tennis legend's last outing at home
Veteran Leander Paes' final ATP Tour match on home soil ended on a disappointing note as he and his partner Matthew Ebden lost to Indian pair of Purav Raja and Ramkumar Ramanathan in the men's doubles final of the Bengaluru Open
The 22-year-old Ocleppo knocked out 13th seeded Ilya Ivashka of Belarus 7-6(4), 6-7(3), 6-4 in a three-setter that lasted two hours and 40 minutes
Bengaluru Open 2020: Prajnesh Gunneswaran, Sumit Nagal suffer loss in pre-quarter-finals; Leander Paes-Matthew Ebden enter semis
Country's ace players Prajnesh Gunneswaran and Sumit Nagal lost in the pre-quarterfinals, ending India's challenge in the men's singles event of the Bengaluru Open.
Bengaluru Open 2020: Leander Paes enthralls crowd in win; Prajnesh Gunneswaran stretched en route to second round
A near-capacity crowd cheered retiring Indian tennis legend Leander Paes as he and his partner Matthew Ebden eked out a straight sets win to advance to the second round of the men's doubles in the Bengaluru Open on Wednesday.
Maharashtra Open 2020: Jiri Vesely, Ricardas Berankis storm into men's singles semis with come-from-behind victories
Jiri Vesely and second seed Ricardas Berankis stormed into the single semi-finals of the ATP Tata Open Maharashtra after scoring come-from-behind victories on Friday.
Maharashtra Open 2020: Emotions and nostalgia in the air as Leander Paes gets ousted from last ATP Tour event in India
Emotions and nostalgia in the air as Leander Paes gets ousted in quarter-finals of Tata Open Maharashtra, his last ATP Tour event in India.
Maharashtra Open 2020: India's Sasi Mukund goes down fighting to Japan's Taro Daniel to make first-round exit
Sasi Mukund, who was handed a wild-card entry lost 2-6, 6-7 (7) in the opening round of the ATP 250 event.
Tata Open Maharashtra 2020: Defending men's doubles champions Divij Sharan and Rohan Bopanna to play with separate partners
Former Grand Slam doubles champions Robert Lindstedt and Jonathan Erlich will be the main attractions at the doubles event of the Tata Open Maharashtra
Atlanta Open: Australians Alex de Minaur, Bernard Tomic register straight-set victories to enter quarter-finals
Australians Alex de Minaur and Bernard Tomic captured straight-set victories on Thursday to advance into a quarter-final meeting at the ATP Atlanta Open.
Australian Open 2019: Roger Federer, Rafael Nadal stay on track as Maria Sharapova sets up Caroline Wozniacki showdown
Roger Federer ground out a tough three-set win to make the Australian Open third round for an incredible 20th straight year on Wednesday, with long-time rival Rafael Nadal also safely through in his drive towards an 18th Grand Slam title.
Australian Open 2019: Clinical Rafael Nadal overwhelms Matthew Ebden in straight sets to reach third round
A dominant Rafael Nadal overwhelmed Australia's Matthew Ebden in straight sets to reach the third round of the Australian Open on Wednesday and stay on track for an 18th Grand Slam title.
Australian Open 2019: Rafael Nadal cruises into second round with straight sets win over wildcard James Duckworth
World No 2 Rafael Nadal blazed into the second round of the Australian Open with a 6-4, 6-3, 7-5 demolition of Australian wildcard James Duckworth.
Shanghai Masters: Novak Djokovic cruises into third round with comfortable win; Matthew Ebden stuns Dominic Thiem
A rejuvenated Novak Djokovic has now won all 12 matches against Jeremy Chardy and this victory was never in doubt.
Japan Open: Local hero Kei Nishikori cruises past Benoit Paire; Nick Kyrgios, Kevin Anderson through to round of 16
Nishikori completed a 6-3, 7-5 victory despite late resistance from Paire to avenge a semi-final defeat inflicted by the Frenchman in Tokyo three years ago.
Atlanta Open: Top seed John Isner outlasts Matthew Ebden to set up all-American final against Ryan Harrison
Top seed John Isner booked his spot in his eighth Atlanta Open final, defeating Aussie Matthew Ebden 6-4, 6-7 (6), 6-1 in the semi-finals on Saturday.
Atlanta Open: American John Isner registers impressive three-set win over Mischa Zverev to enter semi-finals
American John Isner showed why he is playing some of the best tennis of his career on Friday, beating Mischa Zverev 7-5, 4-6, 6-1 in the quarter-finals of the Atlanta Open.
Roger Federer will face Australia's world number 60 Matthew Ebden, who defeated Germany's Philipp Kohlschreiber 4-6, 6-1, 6-2, for a place in the semi-finals.
Miami Open: Joao Sousa beats Ryan Harrison to set up David Goffin clash; Matthew Ebden outlasts Gilles Simon
Brazil’s Joao Sousa edged American Ryan Harrison 7-6(4), 7-6(4) in first round action at the Miami Open as unseeded players enjoyed a day in the limelight.