Tottenham were forced to come from behind when Fred Onyedinma swept home at the far post on 25 minutes.
UEFA Nations League: Villa's Jack Grealish receives first England call-up after Marcus Rashford, Harry Winks withdraw
Villa captain Grealish was a surprise absence from Gareth Southgate's initial squad for the Nations League matches after his impressive form helped his club avoid relegation from the Premier League last season.
Vertonghen, who has made 315 appearances for Spurs in all competitions since arriving from Ajax Amsterdam in 2012, has struggled for playing time this season under Portuguese boss Jose Mourinho.
Premier League: Tottenham Hotspur manager Jose Mourinho to hold video training sessions with players amid COVID-19 lockdown
Tottenham Hotspur manager Jose Mourinho and his coaching staff will put players through their paces from home starting Monday as the club holds live video training sessions amid the coronavirus pandemic.
Premier League: Manchester City need to improve next season, says manager Pep Guardiola after Tottenham defeat
City had 18 goal attempts compared to Tottenham’s three, the hosts taking the lead in the 63rd minute when debutant Steven Bergwijn volleyed home with Jose Mourinho’s side’s first attempt on target
Premier League: Debutant Steven Bergwijn scores as Tottenham beat Manchester City; Arsenal held to goalless draw at Burnley
Outplaying and outshooting Tottenham counted for little after second-place City were reduced to 10 men on the hour when Oleksandr Zinchenko's push on Harry Winks to halt a counterattack saw the midfielder shown a second yellow card
Nations League Finals: Harry Kane included in England's 23-man squad; Kieran Trippier, Harry Winks left out
Harry Kane was included in England's 23-man squad for next month's Nations League finals on Monday but Tottenham Hotspur team-mates Harry Winks and Kieran Trippier were both left out.
Champions League: Harry Kane could be fit for Tottenham Hotspur's final against Liverpool, says Mauricio Pochettino
Tottenham Hotspur manager Mauricio Pochettino has said Harry Kane is in a 'very positive situation' and could be fit to face Liverpool in the Champions League final.
Nations League: Injured Spurs duo Harry Kane, Harry Winks included in Gareth Southgate's provisional England squad for finals
England captain Harry Kane was included by Gareth Southgate in his provisional squad for June's Nations League finals despite being injured.
Champions League: Mauricio Pochettino's Spurs need to counter Ajax's possession-based game with patient play
For Mauricio Pochettino's Spurs, the key to unlocking the Ajax puzzle might well be to not try and play the game they want you to.
Champions League: Tottenham suffer setback after Moussa Sissoko is ruled out through injury for first leg of Ajax semi-final clash
Tottenham suffered a fresh blow to their Champions League hopes when Moussa Sissoko appeared to be ruled out of the first leg of their semi-final against Ajax.
Harry Winks scored a winning goal in the third minute of injury time as Tottenham beat Fulham 2-1 to revive their unlikely bid for the Premier League title on Sunday.
Premier League: Perfect time for in-form Tottenham Hotspur to visit Arsenal, says Harry Winks ahead of north London derby
Tottenham outclassed rivals Chelsea and followed it up with a Champions League win over Inter Milan to boost their confidence ahead of the trip to Arsenal.
Jadon Sancho, Mason Mount and James Maddison get first England call-ups; Harry Winks, Ross Barkley recalled
Jadon Sancho, Mason Mount and James Maddison have been given their first senior England call-ups by Gareth Southgate.
Tottenham midfielder Harry Winks has signed a new five-year contract, the Premier League club announced on Thursday.
Premier League: Tottenham need 200 percent focus against Stoke with Champions League spot on line, says Mauricio Pochettino
Mauricio Pochettino urged Tottenham to keep their focus against relegation-threatened Stoke as they seek to nail down a Champions League place, with Harry Kane in line for a starting spot on Saturday.
Premier League: Tottenham Hotspur's fit-again Erik Lamela in line to make return after over a year out
Erik Lamela is in line to make his Tottenham Hotspur return after over a year on the sidelines through injury, manager Mauricio Pochettino revealed on Monday.
Premier League: Spurs boss Mauricio Pochettino says injured Toby Alderweireld could be out until next year
Tottenham Hotspur central defender Toby Alderweireld could be on the sidelines until next year due to a hamstring injury, manager Mauricio Pochettino revealed on Thursday.
International friendlies: England's Gareth Southgate dismisses club-vs-country talk after Harry Kane's withdrawal
England manager Gareth Southgate has dismissed talk of a club-versus-country row following Tottenham Hotspur striker Harry Kane's withdrawal from his squad.
International friendlies: Injury-hit England pegged back by more withdrawals ahead of Germany, Brazil games
England, who play Brazil on November 14, are already missing Adam Lallana, Danny Welbeck, Nathaniel Chalobah, Tom Heaton, Ross Barkley, Dele Alli, Harry Kane and Harry Winks.