Pique limped off in the 70th minute on Saturday as Barcelona drew 1-1 at home against Alaves in La Liga in the team's first outing since the sacking of coach Ronald Koeman.
The 21-year-old, who plays for Adelaide United in Australia's A-League, said on social media on Wednesday: "I'm a footballer and I'm gay."
Barcelona, who recently announced their debt stands at 1.35 billion euros ($1.6 billion), were unable to keep longtime star Lionel Messi because of financial regulations.
The Spanish attacker has not played for Barcelona since suffering a meniscus injury in November 2020. He is not still full fit but his return seems closer now.
Memphis Depay and Eric Garcia, who both started on Sunday, reportedly couldn't have been registered without Piqué's salary reduction.
Messi's memory lingered heavy over the Camp Nou on Sunday despite the removal of a giant photograph of the Argentine superstar from the entrance in the wake of his move to France.
"We will miss him (Messi) a lot because he was a very important player in the history of Barca. But you can't live in the past. Things change and I'm very excited about the team we have this year," Koeman said.
In a dramatic news conference, Laporta said he was not prepared "to put the club at risk" by renewing Messi's contract, with Barca facing huge financial problems ahead of the start of La Liga.
Madrid was the sole host of the inaugural edition of the restructured Davis Cup Finals in 2019. This time the Spanish capital will co-host the tournament along with the cities of Innsbruck in Austria and Turin in Italy.
LaLiga: Barcelona president Joan Laporta preparing club's revamping process, says 'it's the end of a cycle'
Barcelona may finish as low as fourth in the Spanish league, a competition it was challenging for only a few weeks ago before squandering several opportunities to take the lead.
Copa del Rey: Lionel Messi scores twice as Barcelona beat Athletic Bilbao to win 31st domestic Cup title
The cup was won and lost in a whirlwind 12 minutes in Seville, which saw Barca score four times to clinch an emphatic 4-0 victory, with Messi at his devastating best.
Pique has just returned from three months out due to a partial cruciate ligament injury in the same right knee.
Copa del Rey: Martin Braithwaite scores winner as Barcelona beat Sevilla in extra-time, progress to final
Barcelona will face either Athletic Bilbao or Levante, who are 1-1 in their semi-final, in the final on 17 April in Seville.
Barcagate: Understanding Barcelona scandal that led to arrest of ex-club president Josep Maria Bartomeu
Here's everything you need to know about the Barcagate episode that has the football world buzzing since the news of the arrests broke in and dealt a major blow to the club's image.
Champions League: Kylian Mbappe's hat-trick helps PSG outclass Barcelona; Salah, Mane hand Liverpool win over Leipzig
Barcelona, in the second leg, will no doubt draw upon the spirit of their astonishing 'Remontada' in 2017, when they won the second leg 6-1 to overturn a 4-0 deficit from the opening game in Paris.
Champions League: Barcelona coach Ronald Koeman rests Lionel Messi, Frenkie de Jong for Dynamo Kiev clash
Barcelona travel to Ukraine on top of Group G with a perfect nine points after three games, three points ahead of second-placed Juventus.
LaLiga: Barcelona's injury woes worsen as Gerard Pique picks up serious injury in defeat against Atletico Madrid
Pique cried as he hobbled off the pitch during Barca's 1-0 defeat by Atletico Madrid in La Liga on Saturday following a colission with Angel Correa.
Barcelona toasted the resignation of Josep Maria Bartomeu as president on Tuesday by beating Juventus 24 hours later in the Champions League. But not everything has changed.
Barcelona extend contracts of Gerard Pique, Marc-Andre ter Stegen; salaries adjusted temporarily due to pandemic
Barcelona said the agreements for the extensions came after “weeks of negotiations” and included a “temporary salary adjustment” because of the financial difficulties caused by the coronavirus pandemic.
Champions League: We have hit rock bottom, says Barcelona defender Gerard Pique after Bayern Munich mauling
"We have hit rock bottom. This is not the first, nor the second, nor the third time. We are not on the right path," said Pique.