Pavard revealed he briefly lost consciousness during the world champions' 1-0 victory on Tuesday, but still managed to finish the game.
The winner of the match in Lisbon will go through to the Nations League finals, while a draw would keep the group alive until the final Group 3 matches on Tuesday.
Aouar was initially called up last week as a replacement for Nabil Fekir but instead joins the World Cup winner on the sidelines after hurting his thigh during Lyon's 2-1 derby victory on Sunday.
Mbappe, who took part in Monday evening's training session before learning the result of his test, is the seventh Paris Saint-Germain player to contract the virus. Neymar was among the first to test positive last week.
Coronavirus Outbreak: England football coach Gareth Southgate agrees to 30% pay cut, World champions France send support to hospital workers
Kylian Mbappe and Paul Pogba were among the stars in a video released by the French football federation expressing their gratitude to the country’s under-pressure health workers
Benzema has not played for France since 2015, when he was placed under formal investigation over the blackmail attempt.
Antoine Griezmann: The Making of a Legend review — Charts the topsy-turvy, dramatic life of a modern football star
Despite the initial reservations about a documentary focusing on a player who’s years away from retirement, especially one explicitly declaring him a legend in the title itself, Antoine Griezmann: The Making of a Legend turns out to be a rewarding, neatly structured watch.