Rafa Nadal is aiming for a 12th Masters title in the principality ahead of his pursuit of a 14th French Open success and a record 21st Grand Slam.
"It's been a long and tough road for me," said Federer, who hasn't played a match since a semis defeat to Novak Djokovic at the Australian Open in January 2020, 405 days ago.
Here's a look at Djokovic's incredible run of success and the records he has set on the way to becoming the undoubted king of Melbourne Park:
Novak Djokovic’s Australian Open dominance improved to 18-0 combined in semi-finals and finals. On Sunday, Daniil Medvedev joined the ranks of Roger Federer, Rafael Nadal, Andy Murray, Stan Wawrinka, Dominic Thiem, all of whom have lost to Djoko in semis or finals in Melbourne.
"For sure he has more experience, but more things to lose," Medvedev said about his final opponent Novak Djokovic.
Australian Open: Rafael Nadal says he's 'still not ready' as star reveals he'll sit out ATP Cup clash against Greece
The Australian Open gets underway on Monday with Nadal, the 2009 champion, looking to edge ahead of Roger Federer, who also has 20 Slam titles to his name.
Novak Djokovic has already clinched the year-end number one ranking for the sixth time as he heads into the ATP Masters starting at London's O2 Arena on Sunday.
Roger Federer's the best but Novak Djokovic remains Rafael Nadal's most difficult opponent, says ex-coach Toni
The “GOAT” (Greatest of all Time) debate in men’s tennis has divided opinion for a decade and remains a hot topic as the trio continue to dominate, having won the last 13 majors.
Coronavirus Outbreak: Roger Federer and wife Mirka donate one million Swiss Francs to vulnerable families
Tennis great Roger Federer and his wife Mirka have donated 1 million Swiss Francs (approximately Rs 7.7 crore) to help the most vulnerable families in Switzerland during the coronavirus pandemic.
Wimbledon 2019: Playing on his own terms, Roger Federer takes down Rafael Nadal for another final foray
Before 2017, Roger Federer had a losing 23-11 head-to-head record against Nadal. He has improved to 5-1 since. His only loss came at the French Open semi-finals last month.
Roger Federer made his Wimbledon debut in 1999 with a first round defeat 3-6, 6-3, 6-4, 3-6, 4-6 against Jiri Novak. He was the junior number one in the year and 103rd in ATP rankings coming into the grass court major.
Wimbledon 2019: Swiss ace Roger Federer readies to defy age to lift ninth title at SW19, twenty years after indifferent debut
Federer, who turns 38 in August, is already the oldest player to win the Wimbledon men's title in the modern era, a feat achieved in 2017 when he was 35.
Firstpost Editor's Picks: Mamata Banerjee and 'cut money' row, India-China's NSG deadlock, Federer wins Halle Open; today's must-read stories
Firstpost Editor's Picks: Amid BJP's rise in West Bengal, controversies like cut money row could cost Mamata Banerjee, China continues to block India's NSG bid, Federer wins 10th Halle Open title, 44th anniversary of the 1975-76 Emergency; today's must-read stories
Miami Open 2019: Roger Federer's ever-sharp mind is proving to be the elixir of his glittering career
Was it just good fortune, as Federer put it, that he managed to stay the course till the very end in Miami? Or was it better planning and execution? Every match of Federer’s up to the final showcased a different game plan.
Miami Open: Roger Federer sweeps aside struggling John Isner in final to clinch 101st title of storied career
Roger Federer lifted the 101st title of his remarkable career on Sunday in dominating style, beating ATP Miami Open defending champion John Isner 6-1, 6-4.
Novak Djokovic beats Juan Martin Del Potro in US Open final to win 14th Grand Slam and equal Pete Sampras' record
Novak Djokovic capped off an eventful edition of the US Open by winning the final 6-3, 7-6, 6-3 against Juan Martin Del Potro to pick up the 14th Grand Slam of his career.
Alexander Zverev,Dominic Thiem, Nick Kyrgios and Andrey Rublev will be the major contenders to break the hold of the 'Big four', when they take part in US Open 2017.
Australian Open 2017: Serena Williams' stellar journey, from playing on potholed courts to winning 23 Slam titles
Serena Williams played tennis on potholed courts in one of America's most notorious gangland neighbourhoods, but against the odds, she rose to the top to become a legend.
When Andy Murray wears the Great Britain jersey his game seems to elevate above its usual level. We caught a glimpse of this when he beat Kei Nishikori.
Federer hasn't bested the runaway world number at a major since the Wimbledon semi-finals in 2012, when he last won a Grand Slam title. But when asked if he could beat Djokovic again on the big stage, he bristled.