Napoli ended in second place, two points ahead of Leicester, and will feature in the Europa League knockout round play-offs in February.
Real Betis, Lazio, Monaco, Galatasaray and Olympiakos also qualified for the knockout stages on Thursday.
Leicester have work to do after being held 1-1 at home by Spartak Moscow.
The Minister, Gerald Darmanin, said groups of the Lazio faithful had persistently caused trouble not only around the stadia but also in city centres.
Lyon have also made a perfect start to the European campaign and came from behind to edge Sparta Prague 4-2.
Europa League: Czech Foreign Minister demands apology from Scottish FA for comments about schoolchildren
The children booed Rangers midfielder Kamara until he was sent off following a second booking in the 75th minute, apparently in retaliation after he was allegedly racially abused by a Slavia Prague player last season.
Europa League: Leicester City, Napoli suffer shock defeats; race row mars Rangers-Sparta Prague game
A much-changed Leicester went down 1-0 to Legia Warsaw in Poland, while Napoli's unbeaten record this season was ended by Quincy Promes' double for Spartak Moscow in a thrilling 3-2 win for the Russians at the Diego Maradona stadium.
Bayer Leverkusen were also winners in Group G as the Germans came from behind to beat Ferencvaros 2-1 thanks to a second-half winner from 18-year-old star Florian Wirtz.
UEFA Europa League, Europa Conference League: When and where to watch the matchday 1 games as second and third tier competitions in Europe gets underway.
Chelsea boss Thomas Tuchel won the men's coach of the year prize with Barcelona's Lluis Cortes winning in the women's category.
With almost the entire campaign still left to be played, and United looking like favourites to win silverware for the first time since 2017, here's a quick run-through of an interview the Spaniard had on the Star Sports network.
Introduced in 1965, the rule was used to determine the winner of a two-legged knockout tie in cases where the two teams had scored the same number of goals on aggregate over the two matches.
Europa League: Manchester United's Marcus Rashford racially abused on social media following team's defeat in final
United, who lost 11-10 on penalties, later tweeted to say their players had been subjected to "disgraceful racist abuse".
Manchester United's erroneous tactical change in Europa League final, 'Wu Wei' factor and other talking points from their season
Not just on Wednesday, United have often in big matches took on the role of a team underplaying themselves. In the end the match took on the form of a callous bar fight with the inebriated participants missing more punches than they hit, and often landing one on themselves until one eventually trips on the barstool. United tripped on the bar stool.
There are many factors to the club’s success, but one of the most common answers when this question is brought up is that the Villarreal academy is the driving force of their achievements.
Europa League: Villarreal boss Unai Emery says players didn't practice penalties after team's historic triumph
Villarreal finished seventh in LaLiga, but the win over United sees them jump from next season's inaugural Europa Conference League into the Champions League group stage.
The first 21 penalties were successfully converted before De Gea had his attempt palmed away by Rulli as United lost for the sixth time in seven shootouts, handing Emery a record fourth Europa League crown.
Up to 30 attackers may have been involved, Gdansk police spokesman Michal Sienkiewicz told Polish broadcaster TVN24 on Wednesday. They left before police arrived, he said.
Europa League: Manchester United aim to end four-year wait for trophy against first-time finalists Villarreal
United's last trophy came in the 2016-17 Europa League under Jose Mourinho, when they beat Ajax 2-0 in Stockholm to become just the fifth club to win all three major UEFA competitions.
Europa League: High stakes for Unai Emery as Villarreal aim for final shock against Manchester United
An upset against the much-fancied United would not only clinch Villarreal their first ever major trophy but also a place in Europe's premier tournament next season.