Atletico extend their advantage at the top of the table from one to three points over Real while Barcelona, who now have a game in hand after winning the Copa del Rey final on Saturday, are five points back.
A run of poor results over the past two months has whittled Atlético's once double-digit advantage down to the slimmest of margins. After two straight games without a victory, Real Madrid are now only one point behind and Barcelona are two points behind with eight games left.
With Liverpool to come in the Champions League and a Clasico against Barcelona, Madrid welcomed a comfortable win thanks to goals from Marco Asensio and Karim Benzema.
Leicester are chasing a double over the leaders after a stunning 5-2 win at the Etihad Stadium in September. Former City striker Kelechi Iheanacho is in fine form after scoring seven goals in his last four games for Leicester.
LaLiga: Lionel Messi stars in Barcelona's 3-2 comeback win over Real Betis; Real Sociedad ease past Cadiz
Messi showed why Barcelona agreed to keep him an extremely rich man when on Sunday he acted as Ronald Koeman’s super-sub, scoring one goal and setting up another to help Barcelona earn a 3-2 win at Real Betis.
Militao was shown a red card in the ninth minute at the Alfredo di Stefano Stadium, with his team already without their injured captain Sergio Ramos and COVID-stricken coach Zidane.
LaLiga: Atletico Madrid come from behind to beat Valencia 3-1; Barcelona down Elche 2-0 without suspended Lionel Messi
Coming from behind for a second straight time, Atletico defeated Valencia 3-1 on Sunday to strengthen their hold on the league lead entering the second half of the season.
Another late victory for Atletico means they pull seven points clear of second-placed Real Madrid and 10 ahead of third-placed Barcelona, with another game in hand over both still to come.
Valencia ended an eight-game winless streak and moved further from the relegation zone with a 1-0 win at Valladolid in the Spanish league on Sunday.
The 28-year-old Brazilian required the operation to mend a torn meniscus after he limped off the pitch late in Tuesday's home draw with Eibar.
LaLiga: Lionel Messi-less Barcelona held 1-1 by Eibar; Jose Morales' brace helps Levante edge Real Betis
With Lionel Messi nursing his ankle in the stands, Barcelona fell further behind in the Spanish league on Tuesday after ceding their first-ever point to Eibar at Camp Nou.
LaLiga: Real Madrid draw level with Atletico Madrid after 3-1 win over Eibar; Granada beat Real Betis
Real sit behind Atletico on goal difference, but have the better head-to-head record, which is how level teams are split at the end of the season.
Eibar remains winless in seven home games in the league this season
Pellegrini has been trying to rebuild his team without Spain midfielder Sergio Canales, who injured a tendon two weeks ago with the national side and is expected to be out until next year.
LaLiga: Unbeaten Atletico Madrid take top spot; Lionel Messi rescues Barcelona off the bench as Ansu Fati suffers injury
While Messi got Barcelona back on track, Joao Felix’s latest double helped Atletico Madrid rise to the top of the league with a convincing 4-0 rout of Cadiz.
LaLiga: Real Betis climb to top of league table with win over Valencia; Villarreal hold Atletico Madrid to goalless draw
Atletico Madrid struggled again with Luis Suarez in attack, and were held by Villarreal for their second straight 0-0 draw. Meanwhile, Eibar claimed a 2-1 victory over Valladolid.
Eibar needed goalkeeper Marko Dmitrovic to step up to salvage a 0-0 draw with Celta Vigo at home in their first LaLiga match of the season.
LaLiga: Villarreal's Santi Cazorla, Bruno Soriano to leave club after final league game against Eibar
Spanish media reported Cazorla is off to Qatari side Al Sadd, coached by former Barcelona and Spain midfielder Xavi Hernandez.
LaLiga: Sevilla practically seal Champions League spot with fourth straight win, Eibar stay up, Leganes still alive
Lucas Ocampos opened the scoring for Sevilla with a first-half penalty while Youssef En Nesyri sealed the victory late on, latching on to a long punt from goalkeeper Bono and barging past a defender to lift the ball over Mallorca keeper Manolo Reina.
The come-from-behind victory in Bilbao left Sevilla tied on points with third-place Atlético Madrid and increased its gap to fifth-place Villarreal to six points with three rounds to go. Only the top four qualify for next season's Champions League.