McGregor, 32, will be chasing his first victory since January 2020 while the 31-year-old Poirier (27 wins, five defeats) will be looking for a third consecutive victory.
The 32-year-old McGregor had been an overwhelming favourite to register a winning return after a year away from the octagon.
Poirier, who now has a UFC record of 27-6, used low calf kicks in an effort to put McGregor (22-5) off his usual ferocious stand-up game — and it worked
Conor McGregor vs Dustin Poirier 2 preview and prediction: Plucky Irishman to pick apart American in short order
The blueprints to defeat McGregor exist. Like Nate Diaz, you have to be insanely durable, take his best shot and keep coming forward Terminator-like.
McGregor (22-4) was last seen demolishing American welterweight Donald Cerrone (36-15) via a knockout in just 40 seconds at UFC 246 in Las Vegas last January
A frustrated McGregor, who had previously announced multiple retirements before returning to the octagon, said in July he had retired.
As Jon Jones-Israel Adesanya trash talk threatens to devolve into unseemly spectacle, UFC misses danger signs yet again
Personalities sell. Rivalries sell. Trash talk sells. It also helps if you can fight well. Here's a look at the endless trash-talk culture that has associated itself with boxing and MMA.
Pacquiao vs McGregor may result in plenty of dollars for UFC star, but risk far outweighs the reward
The upcoming bout between Filipino legend Manny Pacquiao and Conor McGregor is likely to be different from the MMA star's foray with Floyd Mayweather Jr. It is because while Mayweather did not knock McGregor out senseless, Pacquiao can do precisely that.
Manny Pacquiao camp says Conor McGregor fight being considered, acknowledge 'tremendous global event'
Sean Gibbons, president of Manny Pacquiao Promotions, said a fight between the eight-division world champion and McGregor would be a "tremendous global event."
Conor McGregor released without charges after being taken into custody in Corsica for alleged sexual assault, indecent exposure
Conor McGregor, no stranger to controversy, was taken into police custody on suspicion of attempted sexual assault and indecent exposure, was released on Saturday without being charged, his lawyer said.
UFC lightweight world champion Khabib Nurmagomedov’s father and longtime trainer, Abdulmanap, has passed away. According to reports, he died due to complications arising from coronavirus.
UFC President Dana White has already said McGregor is next in line for a title shot at the winner of lightweight champion Khabib Nurmagomedov's bout with Justin Gaethje this summer.
UFC 249: Tony Ferguson likens fighting in empty arena in Jacksonville to Ultimate Fighter experience
UFC 249 fight card isn't full of stars, due to the coronavirus enforced restrictions, but is expected to be a much-watched affair, however not in the arena.
Floyd Mayweather went undefeated during his storied career and will now hope to maintain that dominance in simulated bouts after agreeing to put his digital likeness up against other boxing greats
Conor McGregor's opening punch bloodied Donald Cerrone's nose. He then floored Cerrone only 20 seconds into the bout with a perfectly placed kick to the head, and he mercilessly finished on the ground.
McGregor hasn't fought since losing by submission to Khabib Nurmagomedov in October 2018. He was banned for six months and fined $50,000 for his part in a post-fight brawl.
Miami court drops robbery, criminal mischief charges against MMA fighter Conor McGregor after victim withdraws case
McGregor was accused of smashing and stealing a fan’s phone outside a Miami Beach hotel. Prosecutor Khalil Madani announced in court that the victim has recanted his version.
"McGregor couldn't reach a deal with the UFC and it's so they feel they've lost him and they could lose money. I don't think he's finished," Nurmagomedov said.
Mixed martial arts star Conor McGregor under investigation for sexual assault in Ireland, claims media report
Mixed martial arts star Conor McGregor is under investigation in his native Ireland on an accusation of sexual assault, according to a media report which came a day after the trash-talking UFC star announced that he had decided to retire from his career inside the octagon.
UFC star Conor McGregor calls time on mixed martial arts career after series of legal issues following Khabib Nurmagomedov loss
Conor McGregor, one of the most bankable stars in the UFC, had previously vowed to retire in 2016 in a move that was widely seen as a negotiating gambit.