Did you know germs can also cause type-1 diabetes?
Germs could play a role in the development of Type-1 diabetes by triggering the body's immune system to destroy the cells that produce insulin, suggests new research.
London: Germs could play a role in the development of Type-1 diabetes by triggering the body's immune system to destroy the cells that produce insulin, suggests new research.
Type-1 diabetes is a very serious and hard to treat condition affecting mainly young people and children.
Previous research has shown that killer T-cells – a type of white blood cell that normally protects us from germs -- play a major part in type-1 diabetes by destroying insulin producing cells, known as beta cells.
"The study identified part of a bug that turns on killer T-cells so they latch onto beta cells. This finding sheds new light on how these killer T-cells are turned into rogues, leading to the development of type-1 diabetes," said lead author Andy Sewell, professor at Cardiff University in Britain.
These killer T-cells are strongly activated by some bacteria.
During type-1 diabetes, the T-cells attack pancreatic beta cells -- which make the insulin essential for control of blood sugar levels.
When beta cells are destroyed, patients have to inject insulin every day to remain healthy.
"Killer T-cells are extremely effective at killing off germs, but when they mistakenly attack our own tissues, the effects can be devastating," Sewell said.
The research, published in the Journal of Clinical Investigation, provides a first ever glimpse of how germs might trigger killer T-cells to cause type-1 diabetes, but also points towards a more general mechanism for the cause of other autoimmune diseases.
"Finding the cellular mechanisms behind the development of autoimmune diseases, such as type-1 diabetes, could lead to treatments that help us lead longer, healthier lives," David Cole from Cardiff University noted.
The vaccination for children between the 12-14 age group started on 16 March with Biological E's intramuscular vaccine Corbevax, which is administered to the beneficiaries in an interval of 28 days
Monkeypox: Remain vigilant, send sick passengers' samples from affected nations to virology institute, Centre tells officials
According to the WHO, Monkeypox typically manifests in humans with fever, rashes and swollen lymph nodes and may lead to a range of medical complications
The coronavirus death toll climbed to 5,24,181 with 24 fatalities, the data updated at 8 am stated