Sporting defender Luis Neto will take Pepe's place in coach Fernando Santos' squad, the FPF said in a statement on Sunday evening.
Premier League: Arsenal stage second-half comeback to beat West Ham United and end seven-match winless run
Arsenal scored three quickfire second-half goals through Gabriel Martinelli, Nicolas Pepe and Pierre-Emerick Aubameyang to beat West Ham United 3-1 away as they ended a seven-match winless run in the Premier League on Monday.
Pierre-Emerick Aubameyang says Arsenal could try to fight fire with fire on Saturday by deploying him in a front three alongside Alexandre Lacazette and Nicolas Pepe when they travel to face Liverpool in the Premier League.
Africa Cup of Nations 2019: Ivory Coast coach Ibrahim Kamara defends team selection after quarter-final exit, says tournament an internship for youngsters
Ivory Coast coach Ibrahim Kamara appeared confident that his side were on the right path for the future despite quarter-final exit against Algeria
Euro 2020 qualifiers: Cristiano Ronaldo fires blank on international return as stubborn Ukraine hold Portugal
Ukraine snuffed out Portugal on Cristiano Ronaldo's return to international football, defending stoutly as they held the European champions to a goalless draw in their opening Euro 2020 Group B qualifier on Friday.
Champions League: Former Real Madrid duo Iker Casillas, Pepe lead FC Porto's charge as tricky trip to AS Roma beckons
Former teammates for nearly a decade at Real Madrid, veteran duo Iker Casillas and Pepe have been reunited at FC Porto with the Portuguese club hoping their experience can help them reach the Champions League quarter-finals.
FIFA World Cup 2018: Portugal 'privileged' to have player like Cristiano Ronaldo, says defender Pepe
Portugal defender Pepe said it was a "privilege" for the country to have a player like Cristiano Ronaldo after the Real Madrid star's dazzling display against Spain at the World Cup.
FIFA World Cup 2018: Cristiano Ronaldo nets stunning hat-trick as Portugal rescue point against Spain in thrilling clash
Ronaldo's late equaliser capped a storming encounter which came after a chaotic few days which saw Spain coach Julen Lopetegui sacked and Fernando Hierro appointed as his replacement.
Abandoned Turkish Cup semi-final derby between Besiktas and Fenerbahce to resume behind closed doors for 32 minutes
The Turkish Cup semi-final second leg between Besiktas and Fenerbahce will resume behind closed doors next week after violence forced the Istanbul rivals to abandon their ill-tempered encounter on 20 April
Turkish football under the spotlight again for fans’ misbehaviour after Besiktas coach Senol Gunes hit by object
After Besiktas coach Senol Gunes was hit by a projectile from the stands, here's a look at other fan incidents which have tarnished Turkish football in recent times.
Champions League: Bayern Munich look to silence boisterous Besiktas crowd having all but sealed quarter-final spot
Bayern essentially booked their last-eight ticket with a 5-0 demolition of Besiktas in Munich but Heynckes warned about the power of the vocal home support.
An unusual lack of firepower has hobbled Real Madrid with Cristiano Ronaldo and Karim Benzema scoring a meagre four La Liga goals combined and Gareth Bale sidelined with injury.
La Liga: Real Madrid coach Zinedine Zidane insists there is 'no problem' between Cristiano Ronaldo and Sergio Ramos
Zidane added, "They are intelligent people. They have done a lot together, won a lot together and if now and again one person thinks one way and someone else another way, there is no problem."
La Liga: Pepe blasts Real Madrid's fans as unenthusiastic after experiencing cauldron of noise at Besiktas
Pepe left Real for Besiktas in July after winning three Liga titles, two King’s Cup trophies and three Champions League crowns.
First loss in the Champions League group stage in five years and eight points adrift leads Barcelona in the league - are Real Madrid officially in crisis?
After their opening 2-0 loss to Switzerland, Portugal have strung together seven wins for a maximum 21 points, but remain second in Group B three points behind the undefeated Swiss
Raphael Varane has won 13 trophies in his time at the Bernabeu, including three Champions League and two La Liga titles.
La Liga preview: Real Madrid look promising with a settled squad, last season's success likely on menu
With a Neymar shaped headache out of the Camp Nou, a Morata-less Real Madrid should have enough in the tank to win the league
Pepe won three La Liga titles and three UEFA Champions League titles during his time at Real Madrid.