Jamaican star Thompson-Herah powered over the line at Hayward Field in 10.54sec - the second fastest time in history - as Richardson finished a distant last in 11.14sec.
Kenny Bednarek of the United States took silver in 19.68sec while reigning world 200m champion Noah Lyles took bronze in 19.74sec.
After Karsten Warholm's thrilling world-record run in the men's hurdles on Tuesday, arguably one of the best Olympic races in living memory, fireworks are also expected when the women take to the track.
In Bolt's absence, a raft of up-and-coming track and field stars headlined by Swedish pole vaulter Armand Duplantis, US sprinter Noah Lyles, and recent 400m hurdles world record setters Karsten Warholm and Sydney McLaughlin head to Japan looking to build their own legacy.
The International Olympic Committee (IOC) is strictly against any form of propaganda or political statements made during the Games and hence they will be enforcing Rule 50 of their Olympic Charter at Tokyo 2020.
Allyson Felix gets a chance to win a 10th Olympic medal and break a tie with Jamaica's Merlene Ottey as the most decorated female track athlete in the history of the games.
American Lyles, who won gold in the 200 metres in Doha last year, breezed home ahead of Briton Adam Gemili, who crossed the line at 10.28sec, at the second-tier event in Szekesfehervar.
Monaco Diamond League: Joshua Cheptegei breaks 16-year-old 5,000m world record, Noah Lyles' raised fist protest as athletics returns
In perfect conditions, with little wind and temperatures of 27 degrees Celsius (81F), Cheptegei clocked 12min 35.36sec to shatter Ethiopian legend Kenenisa Bekele's previous best of 12:37.35, set in 2004.
World 200m champion Noah Lyles admits long-term psychological problems compounded by pandemic, Olympic postponement, BLM movement
American Lyles, who won gold in the 200 metres and the 4x100m relay in Doha last year and was hotly tipped for the success at the Tokyo Games, announced earlier this month that he was on anti-depressants.
Noah Lyles 'breaks' Usain Bolt's 200m world record in unique high-tech athletics meet, later discovers he ran only 185 metres
Lyles had been mistakenly lined up to run only 185 meters of the Bradenton track for his star turn of this curious version of the storied Weltklasse meet in Zurich on Thursday.
With anti-doping collections severely curtailed across the globe because of the coronavirus pandemic, USADA is asking a group of leading athletes to give urine and small dried blood samples at home
Tokyo Olympics 2020: Canada's Andre De Grasse has opportunity to be part of sprint show after postponement of Games
Andre De Grasse now has the chance to be a major part of the sprint show at the Tokyo Games.
Kenya’s marathon world record holder Brigid Kosgei is among five finalists for the Female Athlete of the Year award after the sport’s governing body, World Athletics, narrowed down the initial list of 11 nominees.
International Association of Athletics Associations removes 200m and steeplechase disciplines from Diamond League 'core' list for 2020
There will be 12 disciplines staged at each of the 15 IAAF Athletics Diamond League meetings with the season beginning in Doha on 17 April.
World Athletics Championships 2019: Despite standout performances, track and field still in search of next big star after Usain Bolt
The debate about the wisdom of bringing the IAAF's biggest competition to a country that is still gearing up to host the biggest in any sport — the 2022 FIFA World Cup — haunted this event from the get-go
World Athletics Championships 2019: Noah Lyles, Christian Coleman target Tokyo Olympics after US renaissance
Christian Coleman, the newly crowned 100m world champion, and Noah Lyles, the victor in the 200m, delivered performances in Doha that suggest they are capable of dominating for years to come.
World Athletics Championships 2019: Noah Lyles produces sensational run to win 200m title, leads American gold rush in Doha
Noah Lyles led a triumphant night for the United States on Tuesday at the World Athletics Championships just hours after the sport had been rocked by the suspension of controversial coach Alberto Salazar.
World Athletics Championships 2019: US sprinter Christian Coleman withdraws from men's 200m citing 'strain'
American Christian Coleman’s dream of adding the 200 metres to the 100 metre world title he won on Saturday has ended after he pulled out of Sunday’s opening round because he was still “feeling the strain”.
A total of 1,972 athletes from 208 countries and territories will compete in the Athletics Championships, which are seen as an important staging post as Qatar prepares for the challenge of hosting football's World Cup in 2022.
World Athletics Championships 2019: From Noah Lyles to Sifan Hassan, three athletes who could shine in global showpiece event
As the World Athletics Championships begins on Friday, we take a look at the three athletes who could shine in the global showpiece, the first since 2003 without Usain Bolt