Thiago and Fabinho are expected to be paired together on Wednesday to try and wrestle control from Madrid's talented triumvirate, but Klopp also has a big decision to make up front.
Liverpool went 68 home league matches unbeaten before a defeat to Burnley in January this year precipitated their improbable losing run that later encompassed Brighton, Manchester City, Everton, Chelsea and Fulham.
Champions League: Liverpool boss Jurgen Klopp insists he's not on revenge mission against Real Madrid
Klopp was asked if he would ever fancy swapping Merseyside for Madrid, but said he is more interested in the Mallorcan sun if he ever moved to Spain.
Firmino has never been viewed as a pure finisher, but criticism of his lack of goals has grown in recent months.
Salah, who has scored eight league goals for Liverpool this season, could miss the Premier League champions' next two matches.
Premier League: How Liverpool's three key forces came together to deliver historic title after 30 years
It took a while for Liverpool to get the right ingredients, but once they had the recipe, Liverpool FC embarked on an unstoppable, inexorable march of clinical performances that bore witness to their greatness.
Premier League: Liverpool on brink of title after thrashing Crystal Palace; Anthony Martial scores hattrick in Manchester United win
Liverpool moved to the brink of a first league title in 30 years with a 4-0 victory over Crystal Palace on Wednesday at an empty Anfield — a stadium that normally has such a raucous atmosphere it has become one of the most intimidating venues in world football for visitors.
Premier League: Liverpool surge to 22 point lead, Leicester City and Chelsea draw, Manchester United held
With nearest pursuers Manchester City playing at Tottenham Hotspur on Sunday, Liverpool increased the gap at the top with a Mohamed Salah double
Champions League: Liverpool boss Jurgen Klopp says there's room for improvement after team's narrow win over Salzburg
Liverpool manager Jurgen Klopp believes even the European champions have plenty of room for improvement after surviving a huge Champions League scare to beat Salzburg 4-3 after blowing a three-goal lead.
Norwich captain Grant Hanley's early own goal set the tone for what could be a long season for the Canaries before Mohamed Salah, Virgil van Dijk and Divock Origi netted as Liverpool shot out of the blocks.
Liverpool Season Preview: Jurgen Klopp's team should intensify pursuit for trophies as new season brings hope with added pressure
Liverpool have to follow last year's blueprint to win the matches, only this time, they have to even be more relentless in their approach. The pursuit for the trophies has to be intensified, and if they end up with multiple titles by next year, this team would've reached its zenith.
2018 in the rearview mirror: From coach Roger Federer to Mo Salah making visually impaired fan's day, most heartwarming moments
As 2018 winds down, here's a list of the most heartwarming stories from sports from the year:
Premier League: Liverpool-Manchester City fixture more than just an ideological encounter between two masterful coaches
Liverpool-Manchester City clash will not decide the Premier League’s outcome but is of vital importance in both teams' quest for supremacy.
Premier League: Jurgen Klopp harnesses Roberto Firmino, Gini Wijnaldum's full potential as Liverpool outflank Tottenham
Jurgen Klopp has understood the strength and weaknesses of each of his players and the part they could best play for the proper functioning of the red machine
FIFA World Cup 2018: Mohamed Salah hitting top gear, Andres Iniesta finding his touch, a fan's wish for Matchday 12
Four matches in a day means another action-packed day at FIFA World Cup 2018. Here's what an Indian fan wants from tonight's fixtures.
FIFA World Cup 2018: Mohamed Salah’s return, Robert Lewandowski vs Sadio Mane among things to watch on Day 6
After an action-packed five days of the FIFA World Cup, here are the storylines to watch out for on Day 6 of the glitzy tournament, including Mo Salah's return and a private duel between Robert Lewandowski and Sadio Mane
Fantasy Premier League Gameweek 31 tips: Pick Liverpool's Mohamed Salah as captain; Wilfred Zaha might fire for Crystal Palace
In a week where only one top six side play, it is easily Liverpool who have the edge over other teams when it comes to their players picked for FPL squads.
Fantasy Premier League Gameweek 30 tips: Time to choose Ederson as goalkeeper and make Harry Kane captain
Ahead of Gameweek 30, here are some of our Fantasy Premier League picks for the week:
Fantasy Premier League Gameweek 25 tips: Pick Nacho Monreal and make Sergio Aguero or Mo Salah the captain
Gameweek 24 was a mixed bag as some old favourites came roaring back into form. With Gameweek 25 upon us, here's a look at what you can do:
Premier League: 'Frustrated' Liverpool manager Jurgen Klopp rues missed opportunities in Swansea City loss
Jurgen Klopp blamed his players for becoming embroiled in a fight at Swansea City as they lost their unbeaten 18-match run to the Premier League's bottom club.