Bopanna and Shapovalov had defeated the pair of Argentina's Guido Pella and Chile's Cristian Garin 6-4, 6-4 to qualify for the round of 16.
Top-ranked doubles player Robert Farah provisionally suspended by International Tennis Federation pending disciplinary hearing
Farah had been due to play in Melbourne with long-time doubles partner Juan Sebastian Cabal until announcing his doping case last week
Australian Open 2020: Men's doubles world No 1 Robert Farah opts out of tournament citing personal reasons
The pair of Farah and Cabal had made the 2018 doubles final at Melbourne Park and were awarded the ATP’s doubles team of the year in 2019
US Open 2019: Juan Sebastian Cabal, Robert Farah become first South American pair to win at Flushing Meadows
Cabal and Farah became the first duo from South America in the Open Era to claim the US Open title
Wimbledon 2019 wrap: 'Big Three' continue to be unstoppable, Serena Williams continues to stutter and plenty of first-timers
Repeat winner in Novak Djokovic, women's winner in Simona Halep, another defeat for Serena Williams, heartbreaking loss for Roger Federer. Wimbledon 2019 witnessed some firsts and few repeats.
Wimbledon 2019: Juan Sebastian Cabal, Robert Farah become first Colombian duo to win Grand Slam men's doubles title
Juan Sebastian Cabal and Robert Farah beat the team of Nicolas Mahut and Edouard Roger-Vasselin to win the men's doubles title at Wimbledon on Saturday
Queen's Club Championships: Andy Murray optimistic about return to tennis after 'life-changing' surgery
Andy Murray has described an operation on his ailing hip as "life-changing" as he prepares to make his return to competitive tennis.
Australian Open 2018: Oliver Marach-Mate Pavic beat Juan Sebastian Cabal-Robert Farah to win men's doubles title
Marach and Pavic, the No 7 seeds, beat Colombians Juan Sebastian Cabal and Robert Farah in the final at Rod Laver Arena 6-4, 6-4.
Bopanna and Babos kept a steady lead throughout the duel and managed to score more winners in both their first and second serves to eke out the victory.
Rohan Bopanna and his Hungarian partner Timea Babos entered the quarterfinals of the Australian Open mixed doubles event with a straight-set win on Tuesday.
Australian Open 2018: Leander Paes-Purav Raja ousted by Juan Sebastian Cabal-Robert Farah in pre-quarters
Veteran Leander Paes and Purav Raja suffered a straight-set defeat at the hands of the Colombian pair of Juan Sebastian Cabal and Robert Farah in the pre-quarterfinals to bow out of the Australian Open on Sunday.
Australian Open 2018: Leander Paes-Purav Raja beat fifth seeds Bruno Soares-Jamie Murray to reach third round
Paes and Raja overcame the Brazilian-Briton team 7-6(3) 5-7 7-6(6) after battling hard for close to three hours.
Cincinnati Masters: Rohan Bopanna, Ivan Dodig reach quaterfinals, Sania Mirza, Shuai Peng earn semifinal spot
Rohan Bopanna and his Croatian partner Ivan Dodig reached the quarterfinals of the Cincinnati Masters after edging past Juan Sebastian Cabal and Fabio Fognini in a tight contest.
It was second consecutive defeat for Ramkumar against the American, having lost to him in the second round of the Roland Garros Qualifier in 2015.
Roger Federer won his 18th Grand Slam title while Serena Williams lifted her 23rd. Take a look at all the Australian Open 2017 champions.
Sania Mirza will have to wait for her seventh Grand Slam trophy as the Indian and her Croatian partner Ivan Dodig lost the Australian Open mixed doubles final 2-6 4-6 to underdogs Abigail Spears and Juan Sebastian Cabal, in Melbourne on Sunday.