Jorge Martin News
The 42-year-old Rossi, a nine-time world champion across categories, took all the applause from the 75000 crowd as he rode an ovation lap in Valencia, which was his 432nd GP since starting his career back in 1996.
The Italian, who celebrated his debut win in the premier category last weekend in Aragon, came under intense pressure from championship leader Fabio Quartararo in the closing laps.
Unlike his rivals who pitted to change bikes, Binder opted to stay out on slick tyres and skillfully held off the field to win his second-ever MotoGP.
On the fastest track in MotoGP, championship leader Fabio Quartararo seemed to have sealed pole position when he smashed the record set last week by fellow Frenchman Johann Zarco last weekend ahead of the Styria Grand Prix.
Marquez has wasted no time getting back in the thick of things nine months after his crash in the Spanish Grand Prix which ruled him out of the entire 2020 season, and the first two races this year.
Spanish rookie Jorge Martin, the teammate of Zarco, was third after starting the race on pole position.
Based in Bologna, Italy, Ducati entered MotoGP in 2003, securing the riders' world title with Casey Stoner in 2007.
Dovizioso avoided a string of crashes and narrow escapes notably that of Yamaha's Franco Morbidelli and Frenchman Johann Zarco.