Bairstow struck 141 not out as the hosts sealed the win with 12 overs to spare to complete a 4-0 series victory.
Catch all the live scores and updates from the fifth ODI between England and West Indies in Southampton.
Mohammed would stand in for regular skipper Jason Holder, who is missing the last match of the tour after returning home to Barbados for the funeral of his uncle, Derrick Garrett, a local sports administrator.
England vs West Indies: Evin Lewis’ breathtaking 176 reiterates Windies have found another Chris Gayle
Given his tenacity and resolve at The Oval, there are many more such knocks to come from Lewis. Gayle's understudy is another dazzler, cloned out of the 38-year-old predator.
England vs West Indies: Jason Holder laments defeat in 4th ODI despite good performances by Evin Lewis, Alzarri Joseph
For all Lewis and Joseph's excellent work, an unbroken partnership of 77 between Moeen Ali and Jos Buttler got England above the required rate to 258 for five when rain stopped play in the 36th over.
Catch all the live updates of the fourth ODI between England and Windies at London.
Ben Stokes was arrested early on Monday morning, 25 September, following an incident in Bristol. Stokes and Alex Hales will not be available for 4th ODI against Windies
England vs West Indies: Liam Plunkett downplays possible Ashes recall, says he's content being ODI specialist
The 3rd ODI saw Moeen Ali hit eight sixes in his 102 and West Indies opener Chris Gayle six in his 94. However, Plunkett still found a way to take 5/52.
Highlights England vs West Indies, 3rd ODI at Bristol: Moeen stars as hosts gain unassailable lead in 5-match series
Follow live scores and updates as England take on West Indies in 3rd ODI at County Ground, Bristol
England vs West Indies: Joe Root refuses to skip ODIs, says playing different formats keeps him refreshed
Joe Root says he will be refreshed rather than fatigued by playing a full part in England's one-day international campaign against the West Indies — even with the Ashes tour looming.
West Indies' agony is Sri Lanka's joy as Jonny Bairstow's ton denies Windies direct WC qualification
Catch all the best moments of the first ODI between England and Windies.
West Indies face World Cup 2019 qualifiers after England loss; Sri Lanka clinch final direct entry spot
England defeated West Indies by seven wickets at Old Trafford on Tuesday, which means the twice former champions can no longer gain direct entry to the 2019 World Cup.
Bairstow is by no means a slow scorer. What he brings to the table is a risk-free attacking approach at the top of the order.
Follow live scores and updates as England take on West Indies in 1st ODI at Old Trafford, Manchester
England white-ball captain Eoin Morgan has urged Ben Stokes to retain his competitive approach despite the prospect of facing longstanding antagonist Marlon Samuels in the first one-day international against West Indies.
This West Indies ODI outfit is a perfect blend of their disorganised Test squad and vibrant T20 squad.
Gayle has scored more than 9,000 runs, including 22 hundreds, in 269 ODIs at a strike rate of 85.11.
England vs West Indies: Jonny Bairstow will open with Alex Hales in first ODI, confirms skipper Eoin Morgan
Bairstow's innings was one of the few crumbs of comfort England could take from a convincing eight-wicket defeat by Pakistan at Cardiff's Sophia Gardens.
That this series victory has come with major contributions from their senior players — Alastair Cook, Joe Root, Ben Stokes and James Anderson — augers well for England.
England vs West Indies: James Anderson's form can help him rise to being highest wicket-taking pacer in Tests
By the close of play on Friday, Anderson had made it to 501 wickets. That means he needs just 63 wickets to become the leading fast bowler of all time in Tests — a milestone that in this kind of form suddenly doesn’t seem all that far away.