This weekend, Barcelona are at home to Atletico Madrid and Real Madrid host Sevilla with six points separating the top four. If this title race needed more drama, the fixture list has provided it.
Real Madrid have it all to do against Chelsea after drawing the opener 1-1 and they are playing catch-up in LaLiga too, after Atletico Madrid had earlier scraped to a 1-0 victory against struggling Elche.
Losing to Athletic Bilbao means Atletico Madrid have won only six of their last 14 league games, with the momentum gained from consecutive wins over Eibar and Huesca proving short-lived.
We take a look at some of the reaction to the news of breakaway European Super League by 12 of the biggest clubs.
Atletico Madrid had been knocked off the top by Real Madrid for the first time since December when they went on to mount a run that saw them go 10 points clear with a game in hand
Marcos Acuna headed in the winner for Sevilla at the Ramon Sanchez Pizjuan, with Atletico's grip on first place loosening even further and their in-form rivals primed to take advantage.
Emerson came off the bench to score the late goal that sealed a comfortable 3-0 aggregate victory over the lacklustre LaLiga leaders.
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"Only one objective: victory," said Simeone, whose team face a 1-0 deficit in the last-16 tie after losing their 'home' game in Bucharest. "I must find the necessary tools to achieve this."
Marcos Llorente's header and a Suarez spot-kick overturned Iker Muniain's opener for Athletic Bilbao, who had dominated the first half.
Luis Suarez's flicked finish early in the first half looked to be enough to give Atletico a crucial win that would have put them eight points clear of their opponents, with a game in hand.
Simeone and Zidane have previously locked horns in the Madrid derby on 13 occasions, 12 times as managers of their respective sides, and once as players.
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Diego Simeone's side had put on a typically disciplined defensive performance until that point but Giroud's moment of genius means they will have to score in London on 17 March if they are to avoid an early exit.
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Seven games into his reign as Chelsea manager, Tuchel remains unbeaten, with the Londoners fifth in the Premier League and into the FA Cup quarter-finals.
Atletico Madrid failed to move eight points clear at the top of LaLiga with the draw.
Barca, who are third and 11 points behind the leaders, face Alaves at home later on Saturday before Real Madrid host Valencia on Sunday.
Lemar and Herrera join Mario Hermoso, Joao Felix and Moussa Dembele on a list of five Atletico players currently out after contracting the illness. Atletico have been hit hard by the virus, with eight players previously having tested positive besides coach Diego Simeone.
Atletico's defeat makes it consecutive seasons they have lost to a third-tier side in the cup after being knocked out by Cultural Leonesa 12 months ago.
Messi headed in from Jordi Alba's cross after his first-half penalty was saved to equal the mark set by the Brazilian great for Santos.
Atletico Madrid can seize control of the LaLiga title race with a win against arch-rivals Real Madrid at Estadio Alfredo Di Stefano.
A first league victory over Barca since 2010 would put Atletico nine points clear of their opponents and extend an impressive unbeaten run in the league to 24 matches.