Brazil have produced a near perfect qualifying campaign, winning 11 of 12 matches — their only blemish a goalless draw in Colombia last month — to qualify with six games to spare.
After their trip to Uruguay, Argentina, unbeaten in 25 matches, host Brazil next week and victories in both could be enough to book their ticket to Qatar.
FIFA World Cup Qualifiers: Brazil register come-from-behind win; Paraguay keep Messi quiet in goalless draw against Argentina
It was a ninth win from nine for the Selecao and extended their lead in the single South American qualifying group to eight points over unbeaten Argentina, who drew 0-0 in Paraguay.
WHO warned the variant was becoming increasingly prevalent in Colombia and Ecuador
The goal was the 24-year-old Porto forward's second of the match and came just 10 minutes after Gianluca Lapadula looked to have sent the game into a penalty shoot-out.
Copa America 2021: Emiliano Martinez's heroics help Argentina edge Colombia on penalties, set up final with Brazil
Argentina won their semi-final against Colombia 3-2 on penalties after three saves by goalkeeper Emiliano Martinez. Regular time ended 1-1 at the Mané Garrincha Stadium in Brasilia on Tuesday.
Copa America 2021: Argentina banking on in-form Lionel Messi to find answer to David Ospina's Colombia
Beat the impressive Ospina and Colombia, and Argentina will take on Brazil in Saturday's decider. The hosts beat Peru 1-0 on Monday and star Neymar ended a news conference by saying he wanted to face Argentina in the final.
Messi has so far scored four goals and assisted four in the tournament.
Copa America 2021: Lionel Messi inspires Argentina to 3-0 win over Ecuador, will face Colombia in semi-finals
Messi scored from a late freekick and earlier laid on two assists as Argentina eventually subdued Ecuador.
The 11th-hour win gave the Selecao a perfect nine points from three matches in the South American championships, and extended their current winning streak to 11 matches.
The point left Ecuador bottom of the five team group on one point, with Venezuela a place and a point above them after having played a game more.
It was a ninth straight win for the Selecao who top Group B with a perfect six points from two games, while Peru fell to the bottom.
Colombia share the Group B lead with Brazil, although the tournament host and defending champions are ahead on goal difference.
FIFA World Cup Qualifiers 2022: Neymar stars in Brazil's win over Paraguay; Argentina blow two-goal lead
Peru earned their first win of the qualification campaign but remained bottom of the group despite a surprise 2-1 success at Ecuador.
The draw leaves Argentina a point behind Brazil, the only remaining side with a perfect qualifying record, who host Ecuador on Friday.
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Copa America is set to kick off on 13 June with the final scheduled for 10 July.
The games that were to be played in Colombia in the 13 June - 10 July event will instead be moved to Argentina, CONMEBOL said
While Brazilian visitors Atlético Mineiro were winning at América de Cali 3-1, the match was interrupted eight times, as sirens and explosions echoed outside Romelio Martinez Stadium in Barranquilla late on Thursday.
Argentina are due to host the opening match of the South American tournament on 13 June. The final will be played in Colombia on 10 July.