The former World no 1 was demolished by the 20-year-old Canadian 6-2, 6-3, 6-4 inside Arthur Ashe Stadium in 2hr 8min.
US Open 2020: Novak Djokovic beats Kyle Edmund to enter third round; Caroline Garcia stuns Karolina Pliskova
Pliskova – the 28-year-old world number three from the Czech Republic – suffered a miserable 1-6, 6-7 exit to a confident Garcia who rushed to a 5-0 lead in the first set.
USTA proposes staging two-tournament bubble, comprising US Open and Cincinnati Open, in New York starting late August
It is far from certain that either US Open or any other tournament in lead up can be played this year, but the maneuver is designed to help draw the needed support of government and public health officials as they manage the outbreak, travel and the economy.
US Open 2019: Rafael Nadal’s improved backhand has made him a formidable hardcourt threat even in Djokovic Era
Armed with an improved backhand to go with the already formidable game he possessed, Rafael Nadal is breaking new ground even at the age of 33.
US Open 2019: Daniil Medvedev says he's proud of his performance despite losing final against Rafael Nadal
Daniil Medvedev said he was incredibly proud of a remarkable six-week hardcourt run in North America that culminated with Sunday's agonizing five-set loss to Rafael Nadal in the US Open final.
US Open 2019: Rafael Nadal edges Daniil Medvedev in gruelling five-set encounter to clinch 19th Grand Slam title
Nadal moved one shy of Roger Federer's record 20 Grand Slams and became the second-oldest New York champion in the Open era after Ken Rosewall in 1970 at 35
US Open 2019, Rafael Nadal vs Daniil Medvedev Highlights, men's singles final: Nadal wins 19th Grand Slam in five set marathon
Catch all the updates from the US Open men's singles final between Rafael Nadal and Daniil Medvedev here
US Open 2019: Emulating past legends, Bianca Andreescu shuts out noise to beat Serena Williams for first Grand Slam title
Bianca Andreescu blocked the noise out at Arthur Ashe Stadium and subdued a fired-up Serena Williams for a stunning victory in the final of the US Open.
Williams said she never expected that she'd have a career spanning more than 20 years and that she feels amazing for having played in different eras of women's tennis
US Open 2019: Grigor Dimitrov comes good on promise, uses deft touch of backhand to down Roger Federer in five sets
Dimitrov won his first match against Federer in eight meetings and has advanced to his second Grand Slam semifinal, having previously reached the last four at Wimbledon 2016
US Open 2019: Elina Svitolina’s determination and discipline take her to first semi-final at Flushing Meadows
Elina Svitolina’s trump card is her discipline. It doesn’t drive crowds to the stands. It is unexciting and unadventurous. But it can be hugely effective, as the Ukranian showed during a clean 6-4, 6-4 win over Konta at the US Open quarterfinals.
US Open 2019: Bianca Andreescu battles past American qualifier Taylor Townsend to reach first ever Grand Slam quarter-final
The match was billed as a clash of styles with Townsend employing the serve-and-volley game, that baffled the fourth-seeded Halep, against the hard-hitting Canadian
In other action, German sixth seed Alexander Zverev will face Argentine Diego Schwartzman while Russian Andrey Rublev meets Italian Matteo Berrettini.
Saturday night's showdown at Arthur Ashe Stadium in the round of 32 might just be the start of a rivalry between the 15-year-old Gauff and World No 1 Osaka
Playing at the Arthur Ashe Stadium, World No 190 Nagal did not let the occasion get the better of him and played some fine tennis to win the first set before going down fighting to the holder of a record 20 Grand Slam titles 6-4, 1-6, 2-6, 4-6.
US Open 2019: Novak Djokovic feeling inspired by prospect of overtaking Roger Federer's all-time Grand Slam title record
Defending champion Novak Djokovic takes inspiration from talk he could pass Roger Federer for the all-time record total of men's Grand Slam singles titles.
US Open 2018: 'Emphatic' Novak Djokovic makes winning Grand Slams look easy again with unrivalled fluidity and flexibility
Novak Djokovic's latest triumph celebrated all the things that make him such a spectacle. His focus was laser sharp, his defence unbreakable
Naomi Osaka becomes first Japanese woman to win Grand Slam title; Serena Williams gets in heated exchange with officials
Naomi Osaka won her first Grand Slam title after beating Serena Williams in a straight sets in a dramatic US Open final by a scoreline of 6-2, 6-4.
US Open 2018: Naomi Osaka says she tried to stay focused on her game as Serena Williams clashed with chair umpire
Naomi Osaka, who earned $3.8 million for the victory, said her next goal was a simple one: to win her next tournament in Tokyo.
US Open 2018: Naomi Osaka wins first Grand Slam title in controversial final as Serena Williams calls chair umpire 'thief'
Osaka triumphed 6-2, 6-4 in the match marred by Williams's second set outburst, the American enraged by umpire Carlos Ramos' warning for receiving coaching from her box.