Kyrgios, no stranger to taking potshots at some of the sport's biggest names, leapt to the defence of 33-year-old Murray who needed a wildcard to play his first clay court tournament in three years.
French Open 2020: Andy Murray says 'difficult' to be former self but vows to 'keep going ' after Stan Wawrinka rout
Andy Murray suffered his joint-worst defeat at a major in terms of games won, succumbing to 2015 Roland Garros winner Stan Wawrinka 6-1, 6-3, 6-2 in the opening day’s marquee match of French Open.
Rafael Nadal, who is seeded second, is aiming to equal the absent Roger Federer's men's record of 20 Grand Slam titles.
Wawrinka, now 35, ranked as high as third in the world in 2014 when he won the Australian Open. He went on to win at Roland Garros the following year and the US Open in 2016.
"As far as renaming the venue (Margaret Court Aena). I think that yes, it's something the sport should consider. I don't know who makes the final decision on that but I don't think her values are what tennis stands for," said Andy Murray.
Murray was also awarded a wild card into the US Open, after his struggles with pelvic and shin injuries dropped his ranking to 129th. He went two rounds in New York, and improved his ranking to 110th.
The French Open which has been pushed back from May to a 27 September start, could host up to 11,500 spectators per day.
The former World no 1 was demolished by the 20-year-old Canadian 6-2, 6-3, 6-4 inside Arthur Ashe Stadium in 2hr 8min.
US Open 2020: Andy Murray secures win after thrilling fightback; Serena Williams, Dominic Thiem progress to second round
Andy Murray fought back from two sets down to win a five-set thriller against Japan's Yoshihito Nishioka, in his first singles Grand Slam match in 18 months because of injury and the coronavirus pandemic.
Ahead of Monday's start of the US Open, the former world number one said the last time he felt this pain-free going into a tennis major was at Roland Garros in 2017.
US Open 2020 Men's Preview: Novak Djokovic's title to lose; potential first-time winners abound in draw
Novak Djokovic is the overwhelming favourite to win the US Open, which starts on 31 August, with multiple players hopeful of lifting their first Grand Slam trophy.
Nishikori, ranked 31, becomes the latest high-profile departure from the tournament, set to begin Monday in a spectator-less quarantine bubble at the US National Tennis Center.
Western & Southern Open: Serena Williams stunned by Maria Sakkari; Novak Djokovic reaches QF with commanding win
Novak Djokovic’s neck felt much better, and his tennis looked much better, in a 6-2, 6-4 victory over unseeded American Tennys Sandgren at the Western & Southern Open on Tuesday that improved the No. 1-ranked man to 20-0 in 2020.
Western & Southern Open: Andy Murray beats Frances Tiafoe to enter second-round; Dayana Yastremska ousts Venus Williams
The 33-year-old Scotsman advanced in hot and humid conditions to a second-round date with German fifth seed Alexander Zverev at the COVID-19 quarantine bubble that will also be used for the US Open, which starts on August 31.
Western & Southern Open: Novak Djokovic, Andy Murray irked by exclusion of Guido Pella and Hugo Dellien
Neither Argentina's Pella or Bolivian Dellien has tested positive for coronavirus since their fitness trainer Juan Manuel Galvan tested positive on Monday. But the pair has been sent into quarantine.
Tennis will be back in full swing as of Saturday, when main-draw action at the Western & Southern Open begins in Flushing Meadows - on the same hard courts that will be used for the US Open
US Open 2020: Former champions Andy Murray, Kim Clijsters receive wild card entry for upcoming Grand Slam
Former world number one Murray, currently ranked 129 after a lengthy period battling a hip injury, narrowly missed direct entry.
Former Wimbledon and US Open champion Murray was given slot alongside Americans Tommy Paul, Tennys Sandgren and Frances Tiafoe for the event, a warm-up for the Grand Slam in New York which begins on 31 August
The US Open, which is due to start on 31 August, will be held without spectators, and organisers are planning to set up a strict bio-security “bubble” around the tournament to mitigate the risk of contracting the virus.
'Gambler' Stan Wawrinka is underestimated, can beat anyone from the Big Four on his day, says his coach Magnus Norman
Wawrinka, 35, was the last man to win a Grand Slam singles title outside the trio of Roger Federer, Rafael Nadal and Novak Djokovic when he won the 2016 US Open.