The Super Eagles, the three-time champions of Africa, failed to win a match in a coronavirus-disrupted 2020.
The Gabon squad, including Arsenal star Pierre-Emerick Aubameyang, were forced to sleep on the floor at a Gambian airport before an Africa Cup of Nations qualifier recently.
Salah, who has scored eight league goals for Liverpool this season, could miss the Premier League champions' next two matches.
Africa Cup of Nations 2021 qualifiers: Michael Olunga inspires Kenya to draw over Mohamed Salah-less Egypt; Algeria thump Zambia
Even without injured Liverpool goal poacher Salah, Egypt were expected to overcome traditional poor travellers Kenya at the vast 87,000-capacity Borg el Arab Stadium near Alexandria.
Africa Cup of Nations qualifiers: Mohamed Salah ruled out of Egypt's clashes against Kenya, Comoros owing to ankle injury
Egypt released a statement on their official Twitter account on Tuesday confirming Salah will miss the games, along with a picture of the striker with a protective boot on his left ankle.
Africa Cup of Nations qualifiers: Mohamed Salah scores last-minute winner to guide Egypt past Tunisia; Morocco beat Cameroon
Mohamed Salah scored in the final minute to give Egypt a 3-2 home victory over Tunisia on Friday in a 2019 Africa Cup of Nations match between two countries who have already qualified.