How genetics, mental health, and even personality decide levels of hangover

After a good night out you may not be surprised when you wake up feeling rough the next morning. But what may surprise you is if your friends aren’t feeling the same way. Some may feel worse, some better and some (if they’re lucky) may not feel any of the negative consequences at all. This is the variability of a hangover. In research, hangovers are measured on an 11-point scale (zero being no effects and ten being extremely hungover). In my own research, participants have reported hangovers on this scale anywhere between one (very mild) to eight (severe) – while other research has estimated around 5 per cent of people may be hangover resistant. So why the difference? There’s more to it than simply how much we drink. Researchers are now starting to explore the many biological and psychological mechanisms that could influence our experience during hangovers. Biological mechanisms Some research suggests that people with a variation of the gene  ALDH2 report experiencing more severe hangovers. When we consume alcohol, it’s broken down by the enzyme alcohol dehydrogenase into acetaldehyde – a protein important for the  emergence of hangover symptoms. However, the ALDH2 gene variant limits the breakdown of acetaldehyde, leading to a greater buildup of the protein – thus greater hangover symptoms. Age and sex can also influence the way in which a hangover is experienced. A recent online survey of 761 Dutch alcohol consumers has found that hangover severity declines with age, even when accommodating for the amount of alcohol consumed. Interestingly, the authors also reported differences in hangover severity between men and women. These sex differences were greater in younger drinkers, with young (18 to 25-year-old) men tending to report more severe hangovers compared to young female drinkers. However, it’s not currently known why these differences exist. Psychological factors Certain psychological traits may be linked to how a hangover is experienced – including anxiety, depression, stress levels and even personality. Previously, research suggested that neuroticism, a broad personality trait which tends to cause people to see the world in a negative way, can predict the severity of a  hangover. However, recently this idea has been disputed with another study finding no link between  hangover and personality. This is somewhat surprising, given that extroversion (a personality trait usually characterised by being sociable and outgoing) is  positively associated with binge drinking behaviours in college students – though it doesn’t appear to be linked to worse hangovers. This is despite evidence that more frequent heavy drinking is linked to  more severe hangover experiences. Anxiety, depression and stress are all also linked with more severe hangovers. Each of these moods are associated with a “negative bias” -– a tendency to interpret the world more negatively.  Our findings show hangovers also tend to make people interpret the world more negatively. As a result, hangovers may exacerbate this negative bias, leading some people to feel worse than others. Coping mechanisms It’s possible that the way we cope with adverse situations could underlie the variation in hangover experiences. Pain catastrophising refers to the extent to which a person emphasises the negative experience of pain. Research shows that people with high scores of pain catastrophising  report more severe hangovers – suggesting that they’re focusing on their negative symptoms and possibly amplifying them. Other studies have also shown that people who tend to cope with their problems by ignoring or denying them tend to experience  worse hangovers. [caption id=“attachment_11826731” align=“alignnone” width=“640”] Biological and psychological mechanisms can influence hangovers. News18 (Representational Image)[/caption] Emotion regulation is another key psychological mechanism that helps us to deal with difficult situations by effectively managing and responding to emotional experiences. Interestingly, although people who are hungover report feeling it’s more difficult to  regulate their emotions, this may not actually be the case – with research showing participants are just as able to control their emotional response compared to those who weren’t hungover. This could mean that people choose easier (but less effective) regulatory strategies during a hangover – such as avoiding feelings of guilt or shame. But this is yet to be determined. What can we do? Although researchers may have identified a few  natural compounds which may alleviate overall hangover symptoms, further research is still needed to determine whether these should be recommended for treatment. In the meantime, the best strategy for  alleviating your hangover is going to be up to you to determine. But one study suggests a strategy commonly used by students to cope with the misery of a hangover – by “suffering” together and  bonding on their experiences – may be helpful in helping relieve at least some of the negative emotional effects of a hangover. Taking care of your own personal wellbeing more generally and finding better strategies to reduce stress levels and adopt better coping mechanisms may also help you deal with the negative consequences of a hangover. Though of course, if you really want to avoid a hangover, you could always choose non-alcoholic alternatives. This article is republished from  The Conversation under a Creative Commons license. 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