UK scientists begin trials of instant immunity antibody drug treatment for COVID-19

The researchers said that through the study, they 'hope to find that giving this treatment via injection can lead to immediate protection against the development of COVID-19 in people'

Press Trust of India December 26, 2020 23:13:48 IST
UK scientists begin trials of instant immunity antibody drug treatment for COVID-19

Representational image. AP

London: Scientists in the UK have begun trials of innovative antibody drug treatments that they hope could provide instant protection against COVID-19 .

The University College London Hospitals NHS Trust (UCLH) said that the researchers in the Storm Chase study believe a Long Acting AntiBody (LAAB) known as AZD7442, developed by AstraZeneca, may offer immediate and long-term protection to people who have been recently exposed to the SARS-CoV-2 coronavirus and prevent them developing COVID-19 .

The study, led by UCLH virologist Dr Catherine Houlihan, recruited the first participant in the world to the study earlier this month and has recruited 10 participants since then.

"We know that this antibody combination can neutralise the virus, so we hope to find that giving this treatment via injection can lead to immediate protection against the development of COVID-19 in people who have been exposed when it would be too late to offer a vaccine," said Houlihan.

UCLH said its new vaccine research centre is running two clinical trials testing a LAAB combination treatment to protect against COVID-19 .

The second Provent study is looking at the use of AZD7442 in people who may not respond to vaccination, for instance where someone has a compromised immune system or are at increased risk of COVID-19 infection due to factors such as age and existing conditions.

We will be recruiting people who are older or in long-term care, and who have conditions such as cancer and HIV which may affect the ability of their immune system to respond to a vaccine.

"We want to reassure anyone for whom a vaccine may not work that we can offer an alternative which is just as protective," said Dr Nicky Longley, UCLH infectious diseases consultant leading the Provent study.

Antibodies are protein molecules that the body produces to help fight infections. Monoclonal antibodies are artificially produced in a laboratory and designed as possible medical treatments. They are designed to be injected directly into the body, unlike vaccines which train the immune system itself to produce antibodies.

These two clinical trials are an important addition to testing new therapeutic approaches, as antibody treatments may offer an alternative to patient groups who cannot benefit from a vaccine, such as immunocompromised patients, said Professor Stephen Powis, the medical director of National Health Service (NHS) England.

The LAABs have been engineered with AstraZeneca's "proprietary" half-life extension technology to increase the durability of the therapy for six to 12 months following a single administration. The combination of two LAABs is also designed to reduce the risk of resistance developed by the SARS-CoV-2 virus, which causes COVID-19 .

"AZD7442 has the potential to be an important preventative and therapeutic medicine against COVID-19 , focusing on the most vulnerable patients. This work complements our vaccine development programme," said Mene Pangalos, AztraZeneca Executive Vice-President for BioPharmaceuticals Research and Development.

"Storm Chaser is exploring the use of a combination of monoclonal antibodies given intramuscularly in those who have been exposed to SARS-CoV-2 a setting where vaccination would not have time to work and we have no other proven therapies to date. This makes Storm Chaser an important study that may have a large impact on our ability to control this infection," noted Professor Andrew Ustianowski, who is the chief investigator of the new studies.

UCLH said that in both Provent and Storm Chaser, researchers will assess whether the treatment reduces the risk of developing COVID-19 and/or reduces the severity of infection compared to placebo.

Key participant groups in the Storm Chaser trial will include healthcare workers, students who live in group accommodation, and patients who are exposed to anyone with the SARS-CoV-2 virus as well as residents of long-term care facilities and industrial/military settings.

Both trials are taking place at the newly-created Vaccine Research Centre at UCLH, which opened this month to help accelerate the development of new vaccines and treatments during the COVID-19 pandemic.

Both Storm Chaser and Provent are crucial to finding a solution to this pandemic, said Professor Vincenzo Libri, who leads the UCLH Clinical Research Facility backed by the UK's National Institute for Health Research (NIHR).

The opening of our new Vaccine Research Centre will help to propel our fight against the virus, meet our aspiration to save as many lives as possible, and ensure a return to normality, he said.

The recent progress on vaccines is hugely welcome, and developing these additional treatments will be vital to ensure everyone in society can be offered protection against COVID-19 , Professor Marcel Levi, UCLH Chief Executive, said.

Updated Date:

Find latest and upcoming tech gadgets online on Tech2 Gadgets. Get technology news, gadgets reviews & ratings. Popular gadgets including laptop, tablet and mobile specifications, features, prices, comparison.

also read

Centre emphasises need to curb proxies ahead of COVID-19 vaccination drive; free jab in Bengal, vows Mamata
India

Centre emphasises need to curb proxies ahead of COVID-19 vaccination drive; free jab in Bengal, vows Mamata

The Central government said on Saturday that India will launch its COVID-19 vaccination drive from 16 January, and priority will be given to nearly three crore health care and frontline workers

Disappointing results from Chinese CoronaVac trial pose a setback for developing nations
science

Disappointing results from Chinese CoronaVac trial pose a setback for developing nations

Many nations that have ordered CoronaVac are relatively poor, desperate to halt the pandemic and protect their population.

SEC recommends Bharat Biotech's COVAXIN for emergency use as India tests its vaccine delivery system
India

SEC recommends Bharat Biotech's COVAXIN for emergency use as India tests its vaccine delivery system

The recommendation for Bharat Biotech's vaccine came a day after the COVID-19 expert panel cleared the Serum Institute of India's emergency use authorisation application for the Oxford-AstraZeneca vaccine 'Covishield'