Orlando: A shooting spree by a heavily armed man at a gay nightclub in Florida early Sunday left 50 people dead, making it the worst mass shooting in US history.
The worst mass shootings in America
Orlando, Florida, 12 June, 2016: Fifty people die and another 53 are injured when a heavily-armed gunman opens fire and seizes hostages at a gay nightclub.
Blacksburg, Virginia, 16 April, 2007: A 23-year-old student of Korean origin goes on a rampage at Virginia Tech University, killing 32 people before committing suicide.
Newtown, Connecticut, 14 December, 2012: A young man kills 26 people, including 20 children at Sandy Hook elementary school. He also fatally shoots his mother. He commits suicide.
Killeen, Texas, 16 October, 1991: A man shoots dead 22 people in a restaurant and then kills himself. Another wounded victim dies later.
Other gun attacks that have marked US history
Littleton, Colorado, 20 April, 1999: Two teenage boys shoot and kill 12 classmates and a teacher at Columbine High School before killing themselves.
Aurora, Colorado, 20 July, 2012: A man kills 12 people and injures 70 more when he opens fire at a movie theater showing a late-night premiere of a Batman film in a suburb of Denver. The gunman James Holmes is given a life jail sentence with no chance of parole.
Fort Hood, Texas, 5 November, 2009: US army psychiatrist Major Nidal Hasan opens fire at his military base, killing 13 people and wounding 42, before being overpowered by police. The shooting was the worst such incident on a military base in the United States.