Exclusive: As Olympics loom, Japanese approval of Moderna's COVID-19 vaccine unlikely till May

By Rocky Swift TOKYO (Reuters) - Moderna Inc's COVID-19 vaccine is unlikely to win approval in Japan until May due to requirements for local clinical trials, the distributor said, casting doubt over a nationwide vaccination rollout before the summer Tokyo Olympics. With an eye on the Olympics due to start in late July, Japan has secured rights to at least 540 million doses of COVID-19 vaccines from several Western developers, the biggest quantity in Asia and more than enough for its 126 million population

Reuters January 09, 2021 00:11:30 IST
Exclusive: As Olympics loom, Japanese approval of Moderna's COVID-19 vaccine unlikely till May

COVID-19 vaccine unlikely till May" src="https://images.firstpost.com/wp-content/uploads/reuters/01-2021/09/2021-01-08T173330Z_3_LYNXMPEH060SC_RTROPTP_2_HEALTH-CORONAVIRUS-JAPAN-MODERNA.jpg" alt="Exclusive As Olympics loom Japanese approval of Modernas COVID19 vaccine unlikely till May" width="300" height="225" />

By Rocky Swift

TOKYO (Reuters) - Moderna Inc's COVID-19 vaccine is unlikely to win approval in Japan until May due to requirements for local clinical trials, the distributor said, casting doubt over a nationwide vaccination rollout before the summer Tokyo Olympics.

With an eye on the Olympics due to start in late July, Japan has secured rights to at least 540 million doses of COVID-19 vaccines from several Western developers, the biggest quantity in Asia and more than enough for its 126 million population.

But Tokyo faces a major regulatory bottleneck due to requirements for local clinical trials before requesting approval. Several other countries have fast-tracked the review process to expedite mass inoculations.

A Japanese trial of the Moderna vaccine, which has already won approval in the United States, Europe, Canada and Israel, is due to start this month.

Masayuki Imagawa, the head of the Japan vaccine business for Takeda Pharmaceutical Co, told Reuters it would likely take several more months to complete the trial and said securing approval in May was "the best case scenario".

Takeda, Japan's biggest drugmaker, is a critical component to Prime Minister Yoshihide Suga's aim to have enough vaccines for the population by June before the Summer Games, currently scheduled to start on July 23.

The company is handling domestic approval and imports of the Moderna shot and local production of Novavax Inc's vaccine, whose development and approval in Japan is further off.

Moderna did not immediately respond to an emailed request for comment.

LOGISTICAL HURDLES

A COVID-19 vaccine developed by Oxford University and AstraZeneca Plc is also being trialed in Japan, leaving a shot developed by Pfizer Inc and BioNTech the only one currently under regulatory review in the country.

Japan has arranged to buy 120 million doses each from Pfizer and AstraZeneca. Through Takeda, it will secure 50 million doses of the Moderna vaccine and up to 250 million of the Novavax formula.

Leaving regulatory hurdles aside, production arrangements and logistical challenges could also complicate vaccine rollouts, as Japan is gripped by a third wave of the pandemic that has been the widest and deadliest yet.

New daily infections nationwide have hit fresh records in recent days, exceeding 7,000 on Thursday. The prime minister has declared a month-long state of emergency in Tokyo and three neighbouring prefectures.

"To achieve the needed production volume, there are various factories to be contracted and tech transfers to be done all over the world," said Imagawa. "And whether that can all really come together to secure enough supply is a remaining challenge."

Pfizer carried out combined Phase I and II trials of its vaccine candidate in Japan in the autumn and said in late December it had applied for approval in Japan for its vaccine, which at the time was already being distributed in Britain and the United States.

Suga said he hoped administering the Pfizer shot could start by the end of February.

AstraZeneca began Japan trials of its vaccine in September but has not yet applied for approval, even as it was approved in India, Britain, Argentina and El Salvador and filed to regulators in South Korea and Mexico.

An AstraZeneca spokeswoman declined to comment on the vaccine's approval or distribution timeline in Japan, citing confidentiality with the government.

Takeda hoped to begin clinical trials of the Novavax candidate next month and, upon approval, it would be mass produced at the company's facility in Yamaguchi prefecture, Imagawa said.

(Reporting by Rocky Swift; Additional reporting by John Miller in Zurich; Editing by Miyoung Kim and Edmund Blair)

This story has not been edited by Firstpost staff and is generated by auto-feed.

Updated Date:

TAGS:

Find latest and upcoming tech gadgets online on Tech2 Gadgets. Get technology news, gadgets reviews & ratings. Popular gadgets including laptop, tablet and mobile specifications, features, prices, comparison.

also read

Germany's Spahn mulls running as chancellor for Merkel's party - Bild
World

Germany's Spahn mulls running as chancellor for Merkel's party - Bild

BERLIN (Reuters) - German Health Minister Jens Spahn is considering putting himself forward to stand as chancellor for Angela Merkel's conservative bloc in a September federal election, top-selling Bild daily reported on Friday. Merkel has said she will not run for a fifth term in the election and her Christian Democrats (CDU) are to pick a new leader next week. The winner would be a favourite to stand as chancellor but someone else could stand, not least because the CDU's Bavarian sister party has to back the candidate.

Australia's Brisbane to enter three-day lockdown after UK COVID-19 variant case
World

Australia's Brisbane to enter three-day lockdown after UK COVID-19 variant case

SYDNEY (Reuters) - Australia's Queensland state will enforce a three-day lockdown in Brisbane, the state capital, from Friday evening after a quarantine hotel worker tested positive for the more contagious variant of COVID-19 that has emerged in Britain. "We know that the level of infection is very high in this particular variant. We have to act differently to what we had before

Sinovac vaccine 78% effective in Brazil trial, experts call for more details
World

Sinovac vaccine 78% effective in Brazil trial, experts call for more details

By Eduardo Simões SAO PAULO (Reuters) - A coronavirus vaccine developed by China's Sinovac Biotech was 78% effective in a late-stage Brazilian trial with no severe COVID-19 cases, researchers said on Thursday, although a lack of data details stirred calls for more transparency. The trial results, closely watched by developing countries counting on the vaccine to begin mass inoculations to help end a raging pandemic, was below preliminary findings from Turkish researchers and lacked detailed data provided on U.S. and European vaccines.