Space travel, long-term exposure to microgravity cause a 'leaky' gut in astronauts: Study

Space travel can disrupt the functioning of the robust cell barrier that lines our intestines to prevent bacteria, fungi, and viruses from invading the rest of our bodies, according to a study. Researchers from the University of California (UC), Riverside in the US noted that the microgravity environment encountered in space has profound effects on human physiology, leading to clinical symptoms and illnesses including gastroenteritis. They suggest that this can greatly increase the risk of infections, and chronic inflammatory conditions such as inflammatory bowel disease, celiac disease, Type-1 diabetes, and liver disease. Previous studies have shown that microgravity weakens the human immune system, in addition to increasing the intestinal disease-causing ability of food-borne bacteria such as salmonella. [caption id=“attachment_5714101” align=“alignnone” width=“1280”] Astronauts in the middle of a spacewalk during Expedition 55 earlier this year. Image: NASA[/caption] The study, published in the journal  Scientific Reports, has implications for understanding the effects of space travel on the intestinal function of astronauts in space, as well as their capability to withstand the effects of agents that compromise intestinal epithelial barrier function following their return to Earth. “Our study shows for the first time that a microgravity environment makes epithelial cells less able to resist the effects of an agent that weakens the barrier properties of these cells,” said Declan McCole, a professor at UC Riverside, who led the study.  “Importantly, we observed that this defect was retained up to 14 days after removal from the microgravity environment,” McCole said in a statement. The permeability-inducing agent the team chose to investigate was acetaldehyde, an alcohol metabolite. McCole explained that alcohol compromises barrier function and increases gastrointestinal permeability in normal subjects and in patients with alcoholic liver disease. The barrier function of the intestinal epithelium, McCole added, is critical for maintaining a healthy intestine. When disrupted, it can lead to increased permeability or leakiness, he said. [caption id=“attachment_7710681” align=“alignnone” width=“1280”]  A leaky gut makes your intestines more permeable to absorption of nutrients and water, but also to their loss. Image: Harvard-Health[/caption] The researchers used a rotating wall vessel — a bioreactor that maintains cells in a controlled rotation environment that simulates near weightlessness — to examine the impact of simulated microgravity on cultured intestinal epithelial cells. Following culture for 18 days in the vessel, the team discovered intestinal epithelial cells showed delayed formation of junctions that connect individual epithelial cells, and are necessary for maintaining impermeability. The rotating wall vessel also produces an altered pattern of the junction assembly that is retained up to 14 days after the intestinal epithelial cells were removed from the vessel. “Our study is the first to investigate if functional changes to epithelial cell barrier properties are sustained over time following removal from a simulated microgravity environment,” McCole said. “Our work can inform long-term space travel and colonisation where exposure to a food-borne pathogen may result in a more severe pathology than on Earth,” he added.