Second woman from controversial gene-edited baby study pregnant: Chinese media

A researcher who claimed to have created the world’s first genetically-edited babies will face a Chinese police investigation, state media said Monday, as authorities confirmed that a second woman fell pregnant during the experiment. He Jiankui shocked the scientific community last year after announcing he had successfully altered the genes of twin girls born in November to prevent them from contracting HIV. He had told a human genome forum in Hong Kong that there had been “another potential pregnancy” involving a second couple. [caption id=“attachment_5624551” align=“alignnone” width=“1280”] He Jiankui during an interview at his laboratory in Shenzhen in China. AP[/caption] A provincial government investigation has since confirmed the existence of the second mother and that the woman was still pregnant, the official Xinhua news agency reported. The expectant mother and the twin girls from the first pregnancy will be put under medical observation, an investigator told Xinhua. The provincial government probe found He had “forged ethical review papers” and “deliberately evaded supervision,” according to Xinhua. He had “privately” organised a project team that included foreign staff and used “technology of uncertain safety and effectiveness” for illegal human embryo gene-editing, it said.

Investigators told Xinhua that the scientist was “pursuing personal fame” and used “self-raised funds” for the controversial experiment. Eight volunteer couples — HIV-positive fathers and HIV-negative mothers — signed up to He’s trial, investigators found, with one couple later dropping out. Details of the experiment — which has not been independently verified — triggered an immediate backlash from the global scientific community and the Chinese government ordered a halt to He’s research work days after it was publicly announced. Speaking at the genome summit in Hong Kong in November, He said he was “proud” of altering the genes of the babies, given the stigma affecting AIDS patients in the country. [caption id=“attachment_5624571” align=“alignnone” width=“1280”] Chinese scientist He Jiankui claimed to have helped make the worlds first genetically edited babies: twin girls whose DNA he said he altered to remove HIV. AP[/caption] But such gene-editing work is banned in most countries, including China. He will be “dealt with seriously according to the law,” and his case will be “handed over to public security organs for handling,” Xinhua reported. The scientist was educated at Stanford University in the US and recruited back to China as part of Beijing’s “Thousand Talents Plan” to reverse brain drain, according to a copy of He’s resume published on the website of the Southern University of Science and Technology in Shenzhen. He’s university has distanced itself from the researcher, saying he had been on unpaid leave since February and had “seriously violated academic ethics”. He said the twins’ DNA was modified using CRISPR, a technique which allows scientists to remove and replace a strand with pinpoint precision. Experts worry meddling with the genome of an embryo could cause harm not only to the individual but also future generations that inherit these same changes.