Firstpost
  • Home
  • Video Shows
    Vantage Firstpost America Firstpost Africa First Sports
  • World
    US News
  • Explainers
  • News
    India Opinion Cricket Tech Entertainment Sports Health Photostories
  • Asia Cup 2025
Apple Incorporated Modi ji Justin Trudeau Trending

Sections

  • Home
  • Live TV
  • Videos
  • Shows
  • World
  • India
  • Explainers
  • Opinion
  • Sports
  • Cricket
  • Health
  • Tech/Auto
  • Entertainment
  • Web Stories
  • Business
  • Impact Shorts

Shows

  • Vantage
  • Firstpost America
  • Firstpost Africa
  • First Sports
  • Fast and Factual
  • Between The Lines
  • Flashback
  • Live TV

Events

  • Raisina Dialogue
  • Independence Day
  • Champions Trophy
  • Delhi Elections 2025
  • Budget 2025
  • US Elections 2024
  • Firstpost Defence Summit
Trending:
  • Charlie Kirk shot dead
  • Nepal protests
  • Russia-Poland tension
  • Israeli strikes in Qatar
  • Larry Ellison
  • Apple event
  • Sunjay Kapur inheritance row
fp-logo
Powerful new gene editing tool adapted from CRISPR-Cas9 can make larger DNA repairs
Whatsapp Facebook Twitter
Whatsapp Facebook Twitter
Apple Incorporated Modi ji Justin Trudeau Trending

Sections

  • Home
  • Live TV
  • Videos
  • Shows
  • World
  • India
  • Explainers
  • Opinion
  • Sports
  • Cricket
  • Health
  • Tech/Auto
  • Entertainment
  • Web Stories
  • Business
  • Impact Shorts

Shows

  • Vantage
  • Firstpost America
  • Firstpost Africa
  • First Sports
  • Fast and Factual
  • Between The Lines
  • Flashback
  • Live TV

Events

  • Raisina Dialogue
  • Independence Day
  • Champions Trophy
  • Delhi Elections 2025
  • Budget 2025
  • US Elections 2024
  • Firstpost Defence Summit
  • Home
  • Tech
  • science
  • Powerful new gene editing tool adapted from CRISPR-Cas9 can make larger DNA repairs

Powerful new gene editing tool adapted from CRISPR-Cas9 can make larger DNA repairs

FP Trending • October 22, 2020, 18:21:59 IST
Whatsapp Facebook Twitter

The new capability to delete or replace long stretches of DNA could help researchers better understand disease conditions and ageing.

Advertisement
Subscribe Join Us
Add as a preferred source on Google
Prefer
Firstpost
On
Google
Powerful new gene editing tool adapted from CRISPR-Cas9 can make larger DNA repairs

A study by UC San Francisco scientists has found a gene editing tool similar to the existing CRISPR-Cas9 method that could be a powerful tool in the study of diseases and in drug development to treat diseases. These processes could advance a lot more quickly with the new tool, which can cut larger pieces of DNA than CRISPR-Cas9 can, from the genetic material in a cell. The UCSF study comes barely two weeks after two researchers were selected for this year’s Nobel Prize in Chemistry, for being the first to use genetic scissors known as CRISPR- Cas9. Lead author of the study Joseph Bondy-Denomy, along with scientists Bálint Csörgő and Lina León, collaborated to develop and test the new CRISPR tool. The CRISPR-Cas3 system, as it is called, was adapted by the UCSF scientists from the widely-known CRISPR-Cas9 model. According to a release by the UC San Francisco, CRISPR evolved ages ago in bacteria as a means to fight viruses known as bacteriophages. Study authors say that when bacteria encounter a phage, they incorporate a bit of the viral DNA into their own DNA to serve as a template to make RNA that binds to the corresponding viral DNA in the phage itself. Subsequently, the CRISPR enzyme targets, disables and kills the phage. The CRISPR-Cas3 system employs Cas3, an important enzyme that acts like a molecular wood chipper to remove long stretches of DNA quickly and accurately. Speaking about the study, Bondy-Denomy said, “Cas3 is like Cas9 with a motor – after finding its specific DNA target, it runs on DNA and chews it up like a Pac-Man.” [caption id=“attachment_7466851” align=“alignnone” width=“1280”]Gene editing as a technology still has a long way to go before being embraced in human trials. Image: Getty Gene editing as a technology still has a long way to go before being embraced in human trials. Image: Getty[/caption] The new capability to delete or replace long stretches of DNA will allow researchers to more efficiently assess the importance of genomic regions containing DNA sequences, and help researchers understand the pathogens that plague them. According to Bondy-Denomu, large swathes of bacterial DNA are poorly understood by CRISPR-Cas3 also should also allow entire genes to be inserted into the genome in industrial, agricultural or even in human gene therapy applications. Researchers modified the CRISPR-Cas3 system used by the bacterium Pseudomonas aeruginosa and showed that their more compact version functions well to remove selected DNA. Researchers programmed the CRISPR system to target specific DNA in the genome of an organism, after which the sequence of DNA coded into the bacteria for repairing the deletions comes into action. The researchers were able to precisely set the boundaries of these large DNA repairs. The results of the study were published in the journal Nature Methods.

Tags
DNA Genetics Genetic engineering gene editing CRISPR UC San Francisco
End of Article
Latest News
Find us on YouTube
Subscribe
End of Article

Top Stories

Charlie Kirk, shot dead in Utah, once said gun deaths are 'worth it' to save Second Amendment

Charlie Kirk, shot dead in Utah, once said gun deaths are 'worth it' to save Second Amendment

From governance to tourism, how Gen-Z protests have damaged Nepal

From governance to tourism, how Gen-Z protests have damaged Nepal

Did Russia deliberately send drones into Poland’s airspace?

Did Russia deliberately send drones into Poland’s airspace?

Netanyahu ‘killed any hope’ for Israeli hostages: Qatar PM after Doha strike

Netanyahu ‘killed any hope’ for Israeli hostages: Qatar PM after Doha strike

Charlie Kirk, shot dead in Utah, once said gun deaths are 'worth it' to save Second Amendment

Charlie Kirk, shot dead in Utah, once said gun deaths are 'worth it' to save Second Amendment

From governance to tourism, how Gen-Z protests have damaged Nepal

From governance to tourism, how Gen-Z protests have damaged Nepal

Did Russia deliberately send drones into Poland’s airspace?

Did Russia deliberately send drones into Poland’s airspace?

Netanyahu ‘killed any hope’ for Israeli hostages: Qatar PM after Doha strike

Netanyahu ‘killed any hope’ for Israeli hostages: Qatar PM after Doha strike

Top Shows

Vantage Firstpost America Firstpost Africa First Sports
Latest News About Firstpost
Most Searched Categories
  • Web Stories
  • World
  • India
  • Explainers
  • Opinion
  • Sports
  • Cricket
  • Tech/Auto
  • Entertainment
  • IPL 2025
NETWORK18 SITES
  • News18
  • Money Control
  • CNBC TV18
  • Forbes India
  • Advertise with us
  • Sitemap
Firstpost Logo

is on YouTube

Subscribe Now

Copyright @ 2024. Firstpost - All Rights Reserved

About Us Contact Us Privacy Policy Cookie Policy Terms Of Use
Home Video Shorts Live TV