In an interview with Game|Life, the vice president of Epic Games, Mark Rein said that they do not intend on bringing the Unreal Engine 3 to the Wii.
He said that the reason for this is that it’s really designed for next-gen, high-definition, so it won’t work with the Wii’s hardware. However, Epic hasn’t completely ignored the Wii. They’re working on other titles for the Wii, such as Red Steel, a Splinter Cell and a Brothers in Arms installment, all of which will use their previous generation engine.