United are second in the Premier League on 65 points, 16 points behind Manchester City and the FA Cup represents their last realistic shot at a trophy this season.
Manchester United's failure to take the game to Sevilla in a match they needed to win to progress puts Jose Mourinho's tactician's plans in poor light.
Champions League: Manager Jose Mourinho says European disappointment nothing new for Manchester United
Mourinho said, "I've sat in this chair twice before with Porto, Manchester United out, and Real Madrid, Manchester United out, so I don't think it's anything new for the club."
United's performance against Sevilla was in stark contrast to their battling 2-1 Premier League win over arch-rivals Liverpool last weekend and Matic said Vincenzo Montella's side deserved to advance.
Champions League: Sevilla stun Manchester United to reach quarter-finals; AS Roma edge past Shakhtar Donetsk
Manchester United crashed out of the Champions League as Wissam Ben Yedder struck twice in four second-half minutes to send Sevilla into the quarter-finals for the first time in 60 years with a stunning 2-1 win at Old Trafford on Tuesday.
La Liga: Real Sociedad's Carlos Vela scores against Sevilla on his final appearance ahead of Los Angeles switch
Sevilla missed the chance to leapfrog Real Madrid into La Liga's top four as Carlos Vela waved goodbye to Real Sociedad with a goal in a 3-1 win for the Basques on Wednesday.
Former Sevilla player Moreno committed the fouls that led to Wissam Ben Yedder's brace, giving the 51st-minute free-kick & the penalty that he converted.
Take look at the key takeaways from Gameweek 5 of the Champions League, including PSG's goal-scoring spree and AS Monaco's dreadful campaign in the group stages.
Berizzo oversaw training on Wednesday following his team fighting back from three goals down at half-time to draw 3-3 with Liverpool at the Sanchez Pizjuan Stadium on Tuesday night.
Klopp blamed Liverpool's lack of Champions League experience in recent seasons for the way they folded after a Roberto Firmino double either side of Sadio Mane's header had given them a 3-0 lead inside half an hour.
Champions League: Cristiano Ronaldo spurs Real Madrid to 6-0 win over APOEL, Liverpool blow 3-goal lead
Ronaldo, who has only scored once in eight La Liga appearances this season, scored his eighth Champions League goal this term with an excellent left-footed finish from a tight angle.
Champions League: Cristiano Ronaldo guides Real Madrid to victory, Harry Kane scores hat-trick in Tottenham win
Cristiano Ronaldo scored twice on his 400th Real Madrid appearance as they defeated Borussia Dortmund 3-1, while Tottenham Hotspur won 3-0 at APOEL Nicosia.
Liverpool's defence hasn't been strengthened this season and defensive lapses once again cost them as Sevilla scored from their only two shots on target.
Champions League: Liverpool held by Sevilla in terse clash featuring two sendings-off and coaching staff spat
Liverpool were undermined by more defensive sloppiness and a missed penalty in a 2-2 draw with Sevilla in a Champions League match that featured two sendings-off and a spat between coaching staff at Anfield
Champions League: Cristiano Ronaldo scores brace on return in Real Madrid win, Tottenham end Wembley jinx
Cristiano Ronaldo grabbed a brace on his return from suspension, as Tottenham Hotspur defeated Dortmund 3-1 and Liverpool were held on their Champions League comeback.