Madrid's night went from bad to worse when Eden Hazard was forced off on 28 minutes after taking a knock, the latest in a long list of injury setbacks for the Belgium star.
LaLiga: Real Sociedad extend lead at top after win over Cadiz; Valencia play out draw against Alaves
Real Sociedad remained in good form after the international break with a 1-0 win over Cádiz on Sunday for their sixth straight league victory and a three-point lead at the top of the standings.
LaLiga: Real Madrid recovery halted by three Valencia penalties and own-goal; Real Sociedad remain top
Madrid took the lead through Karim Benzema but presented Valencia with four gifts at Mestalla, including three spot-kicks and an own-goal scored by Raphael Varane, to fall to another surprise defeat.
LaLiga rules allowed Atletico to buy outside the transfer window after Arsenal activated Thomas Partey's 50 million euro release clause on the last day of the summer transfer window.
Silva opened the scoring with a header on Sunday as Real Sociedad beat Celta Vigo 4-1 to take a one-point lead at the top of the league.
LaLiga: Real Sociedad go top of table with victory over Betis to extend Spanish league's surprise start
Real Sociedad are the sixth different team to lead LaLiga after six rounds of fixtures so far, as Real Madrid gave up their place at the top of the pile after a surprise loss at home to Cadiz on Saturday.
Around European football on Sunday, Gareth Bale would be hopeful of featuring against West Ham in his return to Tottenham. In Spain, Valencia play Villarreal in derby.
Gidey put up the run of her short career a year after taking 10,000m silver at the world athletics championships in Doha.
Getafe had only scored once in their opening two games but struck three times in the first half against Betis, who started the day as league leaders.
Karim Benzema, the heart of Madrid’s title run last season, set up Federico Valverde for the 14th-minute opener, and pressured Emerson into scoring an own goal
LaLiga: Iago Aspas strikes twice as Celta Vigo sink Valencia to climb to second place in points table
Maxi Gomez pulled Valencia level early in the second half only for Aspas to curl a superb free-kick into the top corner as Celta made it four points from their opening two matches.
LaLiga: Valencia register big win in derby against Levante; Real Betis beat Alaves to make winning start
It was a thrilling return to LaLiga for Manuel Pellegrini as Real Betis won 1-0 against Alaves.
Javi Gracia has witnessed something of a firesale this summer at Valencia, with several key players sold and not a single new signing made ahead of the team's opener against Levante on Sunday.
Rodrigo, who can operate as a winger or striker, spent time at Celta Vigo and Real Madrid as a young player before moving to Benfica. He joined Valencia in 2014, initially on lona.
Valencia were starting their pre-season preparations this week under new coach Javi Gracia, who was appointed two weeks ago following the sacking of Albert Celades in June.
Mustafi, 28, sustained the injury during the closing stages of Arsenal’s 2-0 semi-final victory against Manchester City at Wembley last week.
LaLiga: Sevilla practically seal Champions League spot with fourth straight win, Eibar stay up, Leganes still alive
Lucas Ocampos opened the scoring for Sevilla with a first-half penalty while Youssef En Nesyri sealed the victory late on, latching on to a long punt from goalkeeper Bono and barging past a defender to lift the ball over Mallorca keeper Manolo Reina.
LaLiga: Real Madrid attacker Vinicius Junior to take COVID-19 test again after getting 'wrong' result
Zidane says Vinicius Junior's test was not positive, adding that sometimes the tests come back with an error, instead of a positive or negative outcome.
LaLiga: Celta Vigo, Atletico Madrid share spoils in insipid draw, Lee Kang-in ends Valencia's winless streak
Lee scored with a low left-foot shot from outside the area to keep Valencia in the fight for a Europa League spot. They are one point behind seventh-place Real Sociedad with three rounds to go.
Valencia have won only one of seven matches since the league resumed and are ninth in the standings, in danger of missing out on European action next season.