Sumit Nagal's third Grand Slam main draw appearance and first at Australian Open resulted in a largely forgetful first round loss.
Australian Open 2021: Sumit Nagal exits in first round after 2-6, 5-7, 3-6 loss to Ricardas Berankis
Nagal had lost to the world No 72 in the last week's tune-up event too.
Sumit has been awarded a wild card for the main draw and will know his opponent on Thursday when the draw for the rescheduled major is announced.
Australian Open 2021: India's Ankita Raina loses to Olga Danilovic, eliminated in final round of qualifiers
In the women's singles qualifiers being held in Dubai, Ankita lost the third and final round 2-6, 6-3, 1-6 to her Serbian opponent in almost two hours.
Roland Garros 2020: Prajnesh Gunneswaran enters second round of qualifying, Sumit Nagal, Ramkumar Ramanathan exit
Seeded 16th, Nagal — who became the first Indian in seven years to win a singles match at a Grand Slam with his opening-round victory at the US Open — lost 6-7 (4) 5-7 to Germany's seasoned player Dustin Brown in one hour and 47 minutes.
Bopanna is the lone surviving Indian in the tournament after the exit of Sumit Nagal and Divij Sharan.
Rohan Bopanna and his Canadian partner Denis Shapovalov will next play sixth seeds Kevin Krawietz and Andreas Mies.
US Open 2020: Andy Murray crashes out after losing to Felix Auger-Aliassime; Serena Williams, Daniil Medvedev advance
Sofia Kenin continued her impressive form this year with a straightforward 6-4, 6-3 victory over Canadian Leylah Fernandez to progress into the third round of US Open.
As far as 'free' points are concerned, Sumit Nagal had just four (one ace and three return unforced errors from Thiem) - not ideal when playing a top level player with high intensity.
A year on from facing Roger Federer on the Arthur Ashe Stadium, Sumit Nagal has another herculean task at hand in Dominic Thiem.
US Open 2020: Sumit Nagal beats Bradley Klahn, first Indian to win singles Grand Slam match in seven years
Up next for Sumit Nagal will be Austria's top player Dominic Thiem, who prevailed against Spanish rival Jaume Munar 7-6(6), 6-3.
US Open 2020: Andy Murray secures win after thrilling fightback; Serena Williams, Dominic Thiem progress to second round
Andy Murray fought back from two sets down to win a five-set thriller against Japan's Yoshihito Nishioka, in his first singles Grand Slam match in 18 months because of injury and the coronavirus pandemic.
Nagal had also taken a set off another Swiss star and multiple Grand Slam winner Roger Federer in the US Open last year before losing the match.
Prague Open 2020: India's Sumit Nagal sets up quarter-final clash with Stanislas Wawrinka after victory over Kiri Lehecka
Sixth seed and world number 127 Nagal had to battle hard to win 5-7, 7-6(4), 6-3 in the two-hour and 21-minute second round contest against the local player, ranked 617.
Nagal, ranked 127 in the world, was leading 6-3 5-7 4-1, when Clarke decided to call it quits in the second round match after playing for over two hours.
No fans, depleted field, will US Open match wins count for less? Sumit Nagal, Rohan Bopanna weigh in
Instead of contemplating an asterisk next to the winners’ name at US Open 2020, it should instead have an exclamation point.
It will be Nagal's second appearance at the US Open, starting 31 August, and he is the only Indian in the men's field with Prajnesh Gunneswaran, ranked 132, missing out.
Davis Cup 2020: Rohan Bopanna, Leander Paes win in doubles, but Marin Cilic beats Sumit Nagal to secure tie for Croatia
Rohan Bopanna and Leander Paes had kept India alive in the Davis Cup Qualifiers with a three-set victory, but Marin Cilic shattered all hopes with 6-0, 6-1 win over Sumit Nagal and secure the tie 3-1 for Croatia.
Davis Cup 2020: Full-strength India face Croatia with realistic chance of upsetting former champions
Prajnesh Gunneswaran, who missed the last tie because of his marriage, admitted that the lack of a strong second singles player in the rival line-up could work to India's advantage
Bengaluru Open 2020: Leander Paes-Matthew Ebden lose in final at Indian tennis legend's last outing at home
Veteran Leander Paes' final ATP Tour match on home soil ended on a disappointing note as he and his partner Matthew Ebden lost to Indian pair of Purav Raja and Ramkumar Ramanathan in the men's doubles final of the Bengaluru Open