Thiem, 27, captured his maiden Slam in New York against Alexander Zverev, the first major final in six years not to feature at least one of the 'Big Three'. However, US broadcaster ESPN said that ratings for that championship match were down 48%.
Wawrinka, now 35, ranked as high as third in the world in 2014 when he won the Australian Open. He went on to win at Roland Garros the following year and the US Open in 2016.
US Open 2020: 'An amazing fight', Twitter reacts to Dominic Thiem's maiden title at Flushing Meadows
Fans react to Thiem's first grand slam win on Twitter. Here are some reactions.
US Open 2020: Dominic Thiem hopes to play more freely in future after securing career's first grand slam win
The second seeded Austrian thought he was heading for a fourth defeat in Grand Slam finals after going two sets down to fifth seeded German Alexander Zverev at Flushing Meadows.
US Open 2020: Dominic Thiem beats Alexander Zverev in marathon five-setter to claim first Grand Slam title
The title marks Thiem's maiden Grand Slam trophy after three previous defeats in finals of tennis majors.
The eventual champion will be the first man born in the 1990s to grab a Grand Slam trophy: Zverev is 23, Medvedev is 24, Thiem turned 27 a week ago, and Carreño Busta is 29.
Because of concerns amid the coronavirus pandemic, Nadal preferred not to travel to New York for the ongoing US Open. He last played in February, when he won a tournament in Acapulco.
Djokovic said the official, who was hit in the throat by a ball bashed away in anger by the world number one, had "done nothing wrong at all".
Despite his achievements, Novak Djokovic appears doomed never to be held in the same saintly esteem as Roger Federer or Rafael Nadal, the undisputed 'people's champions' of tennis.
Novak Djokovic says he has no hard feeling for Roger Federer, Rafael Nadal for not joining new players' union
Nadal and Federer called for "unity, not separation" after Djokovic revealed at the weekend that he was spearheading a controversial breakaway union for professional male players.
US Open 2020: Sumit Nagal beats Bradley Klahn, first Indian to win singles Grand Slam match in seven years
Up next for Sumit Nagal will be Austria's top player Dominic Thiem, who prevailed against Spanish rival Jaume Munar 7-6(6), 6-3.
Despite being bothered by neck stiffness at times, Djokovic showed he remains the man to beat in the Flushing Meadows fortnight as he challenges for tennis history.
Roger Federer, Rafael Nadal oppose Novak Djokovic's breakaway tennis union, call for 'unity, not separation'
Vasek Pospisil announced the beginning of the Professional Tennis Players Association (PTPA) on Twitter on Saturday with a picture showing a group of male players standing on a US Open court
Nishikori, ranked 31, becomes the latest high-profile departure from the tournament, set to begin Monday in a spectator-less quarantine bubble at the US National Tennis Center.
Should he continue to test positive into next week, World No 31 Nishikori would be in jeopardy of missing the start of the US Open.
Djokovic, who has topped the world rankings for 282 weeks, could overtake Federer's record of 310 weeks at number one by March and said that is a major goal as well.
Nagal had also taken a set off another Swiss star and multiple Grand Slam winner Roger Federer in the US Open last year before losing the match.
Djokovic's decision to take part in the US Open is a major boost for the tournament after a host of headline names pulled out.
It will be Nagal's second appearance at the US Open, starting 31 August, and he is the only Indian in the men's field with Prajnesh Gunneswaran, ranked 132, missing out.