Mikel Arteta has overseen Arsenal's worst start since the 1974/75 season - they have scored just 12 goals to boot - and lie just four points above the relegation zone.
Premier League: Newcastle United players battling exhaustion after string of COVID-19 cases, says Steve Bruce
The Magpies will once again be without a number of unnamed players for Saturday's home match against Fulham as a result of the lingering effects of the Covid-19 outbreak, which prompted the club to close their training ground at the end of last month.
Premier League: United, City share spoils after Manchester derby ends in dull goalless draw; Everton edge past Chelsea
A draw leaves United still one point above City but the Red Devils are now eighth with Pep Guardiola's men ninth.
United's training headquarters had been closed as a result of the spike, which forced the first postponement of a Premier League fixture this season due to COVID-19.
Neither Newcastle nor the Premier League have commented publicly on the situation.
Premier League: Son Heung-min, Lo Celso on target as Tottenham stun Manchester City; Chelsea beat Newcastle United
Spurs ended the day on top of the table for the first time in six years as goals from Son Heung-min and Giovani Lo Celso saw off a toothless City at the Tottenham Hotspur stadium.
Premier League: Chelsea boss Frank Lampard criticises cramped calendar citing concern over player fitness
Chelsea have barely any time to rest or train before the trip to St James' Park on Saturday and Lampard is concerned that their fitness is being put at risk.
Premier League: Southampton go top of table with victory over Newcastle United; Burnley, Brighton play out goalless draw
Goals from Che Adams and Stuart Armstrong ensured Southampton finished the day at the summit of the English top-flight table for the first time since Chris Nicholl's team 32 years ago.
Everton manager Carlo Ancelotti, like many of his fellow Premier League managers, is increasingly concerned by the toll the packed schedule is taking on their players.
City returned to winning ways after an indifferent start to the season, courtesy of a first-half goal from Raheem Sterling, who condemned Arsenal to their seventh straight defeat in league matches between the two sides.
Everton will head into the Merseyside derby against Liverpool after the international break with maximum points from their first four games.
League Cup: Manchester City, United breeze past Burnley, Brighton to reach quarter-finals; Everton also advance
Guardiola's men would have won by an even bigger scoreline but for a fine display from Burnley keeper Bailey Peacock-Farrell.
Premier League: Newcastle snatch late draw against Tottenham after controversial penalty for handball
On a weekend already marked by complaints over the new interpretation of the handball law in the Premier League, Tottenham were stung despite Dier clearly having no intent to handle the ball.
League Cup: Hat-trick for Kai Havertz as Chelsea stroll past Barnsley; wins for Arsenal, Newcastle, Everton
Kai Havertz — signed for $92 million — announced himself in English football by scoring a first career hat-trick in Chelsea's 6-0 win over Barnsley in the third round of the League Cup
Premier League: Gareth Bale 'motivated' to recover from knee injury for second Tottenham debut, says Jose Mourinho
Gareth Bale rejoined the London club last week from Real Madrid on a season-long loan.
Newcastle released a statement on Wednesday that said Premier League chief executive Richard Masters had blocked the takeover and did not "act appropriately".
Premier League: Newcastle United in 'advanced talks' with Singaporean conglomerate over potential takeover
Bellagraph Nova Group, which operates across 100 countries, said it has given Newcastle a letter of intent and proof it has funds for the purchase.
Premier League: Saudi Arabia-led consortium's Newcastle United bid ends over piracy, human rights issues
Premier League spent four months considering whether to approve the 300 million pound takeover of Newcastle that would have seen Saudi Arabia's Public Investment Fund gain an 80 percent stake in it.
Premier League: Newcastle United could be without key players for Brighton clash, says manager Steve Bruce
Fabian Schar and Allan Saint-Maximin are among the key Newcastle players doubtful for Monday’s fixture against Brighton while defender Jamaal Lascelles has been ruled out for the remainder of the season.
Premier League: Brighton eyeing their highest-ever top-flight points tally, says manager Graham Potter
Potter’s side, 16th in the standings and six points clear of the relegation zone, host 13th-placed Newcastle United on Monday before travelling to Burnley.