World number one Djokovic was broken five times by the Briton in their last-16 clash and suffered his first loss of the year, having won the Australian Open for the ninth time in February.
2019 Australian Open semi-finalist Lucas Pouille set to miss out on 2020 edition due to right elbow injury
Pouille announced on Twitter on Monday he will miss the first tennis major of 2020 plus the inaugural ATP Cup in Australia and the Adelaide tournament, all in January
Top-ranked Djokovic, who is attempting to win a title on his tournament debut for the 10th time, needed just 50 minutes at Ariake Colosseum to dispatch the fifth-seeded Pouille 6-1, 6-2 and set up a semifinal with either Hyeon Chung or David Goffin, who won here in 2017.
Goffin, who beat Denis Shapovalov 7-6 (5), 7-6 (2), is the only former champion in the draw. He has made the final in both of his previous appearances, losing to Nick Kyrgios in the 2016 final before defeating Adrian Mannarino for the title in 2017.
Japan Open 2019: Novak Djokovic beats Japanese wild-card Go Soeda in straight sets, will face fifth seed Lucas Pouille in quarter-final
Djokovic had retired with a left-shoulder injury during his fourth-round match against Stan Wawrinka at the US Open but has shown no lingering effects in Tokyo
US Open 2019: Roger Federer 'sick and tired' of suggestions he dictated scheduling at Flushing Meadows after win over Dan Evans
Roger Federer said he was 'sick and tired' at suggestions he dictated the scheduling at the US Open after thrashing Dan Evans, who was hampered by a quick turnaround between matches.
Cincinnati Masters: Novak Djokovic cruises into quarters but Roger Federer crashes out; Ash Barty, Naomi Osaka win
Novak Djokovic has a clear road to the Cincinnati Masters final after producing an efficient victory while Roger Federer crashed out of the US Open tune-up event.
Watch: Nick Kyrgios smashes racquets, abuses umpire in second-round defeat against Karen Khachanov at Cincinnati Masters
Nick Kyrgios stepped off court to smash two racquets and toss his shoes to spectators on Wednesday in a meltdown during a second-round ATP Cincinnati Masters loss to Russia's Karen Khachanov.
Rogers Cup: Canadians Denis Shapovalov, Milos Raonic register straight-sets win; Stan Wawrinka advances
Canadians Denis Shapovalov and Milos Raonic fed off a supportive home crowd to advance in straight sets to the second round of the Rogers Cup in Montreal on Monday.
Wimbledon 2019: Roger Federer beats Lucas Pouille to record 350th Grand Slam win; Serena Williams, Rafael Nadal progress
Federer registered a record 350th win in Grand Slam matches in his 7-5, 6-2, 7-6 (7/4) Wimbledon win over Lucas Pouille of France and in the process reached the fourth round for an unprecedented 17th time
French Open 2019: Roger Feder on collision course with Rafael Nadal, Novak Djokovic faces complicated route to quarter-finals
We analyse and break down the brackets at Roland Garros to see who will play whom, who will win big and what to expect at each stage of the French Open 2019
Madrid Masters 2019 draw analysis: Roger Federer returns, but the bigger story is around Rafael Nadal and Dominic Thiem
Roger Federer and Juan Martin del Potro might be making their comebacks on the clay court, but the bigger story will be around Rafael Nadal and Dominic Thiem.
Monte Carlo 2019 draw analysis: At the Rafael Nadal Open, it’s not looking good for the rest of the field
So which of those poor souls is going to be brave enough to try and wrest the trophy from Nadal’s grasp? Here’s a quick break-down of the draw
Australian Open 2019: Lucas Pouille admits he couldn't find a solution to stop 'amazing' Novak Djokovic in semi-final
Lucas Pouille admitted that world number one Novak Djokovic played so well in their Australian Open semi-final Friday that he was powerless to resist.
Australian Open 2019: Novak Djokovic thumps Lucas Pouille in straight sets to set up final against Rafael Nadal
Novak Djokovic on Friday continued his quest for a record seventh Australian Open crown by swatting aside French 28th seed Lucas Pouille 6-0, 6-2, 6-2 to set up a final against Rafael Nadal.
Australian Open 2019, highlights: Novak Djokovic sets up final against Rafael Nadal after semi-final demolition of Lucas Pouille
Catch all the latest scores and updates from the Australian Open 2019 men's singles semi-final between Novak Djokovic and Lucas Pouille.
Australian Open 2019: Novak Djokovic expects practice partner Lucas Pouille to be fearless in semi-finals
Novak Djokovic says it will be odd to face practice partner Lucas Pouille in the last-four of the Australian Open on Friday, as the world number one continues his quest for a record seventh title.
Australian Open 2019: Rafael Nadal ends Stefanos Tsitsipas' dream run with ruthless three-set win in semi-final
Nadal has not dropped his serve for an astonishing 63 straight games and has not lost a set on his way to the final, where he will face either Novak Djokovic or Lucas Pouille.
Australian Open 2019: With renewed love for tennis, Frenchman Lucas Pouille set to test mighty Novak Djokovic in semi-final
Amelie Mauresmo and Lucas Pouille may only have been a team for a little over a month, but already, Mauresmo has done perhaps what was most crucial for her young charge: renewing his love for the sport both have made their lifelong careers.
Australian Open 2019: Amelie Mauresmo leads rare breed of female coaches making an impact in Melbourne
While Conchita Martinez and Rennae Stubbs have been instrumental in Karolina Pliskova's best run in Melbourne, Amelie Mauresmo has helped Lucas Pouille harness that talent and reach his first ever major semis.