For the first time in Mourinho's managerial career, he has lost back-to-back home league games.
Spurs fielded a strong side featuring Dele Alli, Toby Alderweireld and Lucas Moura, while Harry Kane's replacement Vinicius scored a hat-trick
Premier League: Newcastle snatch late draw against Tottenham after controversial penalty for handball
On a weekend already marked by complaints over the new interpretation of the handball law in the Premier League, Tottenham were stung despite Dier clearly having no intent to handle the ball.
Kane is contracted to Spurs until 2024 but said during an Instagram Live session with Sky Sports pundit Jamie Redknapp last month that he could leave if he felt the London club were not moving in the right direction
Premier League: Dele Alli penalty earns Tottenham draw against Burnley as Jose Mourinho criticises Tanguy Ndombele
Jose Mourinho delivered a withering critique of Tottenham record-signing Tanguy Ndombele after a dire first-half showing from his side in the 1-1 draw at Burnley in the Premier League
Premier League: 'I'm paid to make decisions,' says Chelsea manager Frank Lampard on decision to drop Kepa Arrizabalaga
Lampard defended Arrizabalaga, who cost a world record 80 million euros, earlier this season when the Spaniard was guilty of making critical errors but has benched him in recent matches in favour of 38-year-old Willy Caballero
FA Cup: Heung-min Son's late penalty clinches victory for Tottenham over Southampton and progress to fifth round
Tottenham will host another Premier League club, Norwich, in the fifth round in the first week of March.
Failing to beat relegation-threatened Watford is another blow to Tottenham's hopes of qualifying for the Champions League after reaching last season's final
FA Cup: Wayne Rooney stars as Derby claim shock win at Crystal Palace; struggling Tottenham draw at Middlesbrough
Rooney played the full 90 minutes in his second game for Derby since his return to English football after a spell in the United States with DC United
League Cup: Mauricio Pochettino admits Tottenham squad is 'unsettled' after shock defeat to fourth-tier Colchester
Pochettino's Tottenham were beaten 4-3 on penalties against Colchester after being held to a goalless draw by a club 71 places below them, with Christian Eriksen and Lucas Moura both missing during the shoot-out.
League Cup: Tottenham suffers shock defeat against fourth-tier Colchester; holders Manchester City beat Preston
Tottenham's disappointing start to the season hit a new low as they suffered an embarrassing League Cup third-round defeat on penalties at fourth-tier Colchester on Tuesday.
Champions League: Tottenham boss Mauricio Pochettino raises doubts about team's attitude after draw against Olympiakos
Tottenham manager Mauricio Pochettino questioned his side's attitude after letting a two-goal lead slip to draw 2-2 away to Olympiakos in their Champions League opener on Wednesday.
Premier League: Pep Guardiola's VAR woes continue as Manchester City suffer early setback in title defence
From Moura's goal, until the rather dramatic ending of the match, the game played out in predictable patterns, with spells of Manchester City possession ending in near-escapes and close shaves for Tottenham
Premier League: Manchester City held to draw by Tottenham following controversial VAR decision; Arsenal, Liverpool scrape through
City thought they had stolen three points when Gabriel Jesus fired home in stoppage-time, but their celebrations were curtailed when a VAR review showed Aymeric Laporte had flicked the ball on with his arm
Premier League: Tottenham Hotspur forward Lucas Moura to stay with club till 2024 after signing one-year contract extension
Lucas was a key player in Spurs' run to the final in Madrid lost to Liverpool – also scoring the late group stage equaliser at Barcelona that took them into the last 16 before his semi-final heroics.
International Champions Cup: Angel Gomes scores late winner for Manchester United in bad-tempered clash against Tottenham Hotspur
French striker Anthony Martial put Ole Gunnar Solskjaer's United ahead in the first half, before Spurs substitute Lucas Moura replied with a scrappy effort in the second.
Tottenham's Lucas Moura says he has no grudge against manager Mauricio Pochettino after being dropped in Champions League final
Pochettino preferred to use Harry Kane in attack against Liverpool in Madrid despite a lengthy absence following injury.
Champions League player ratings: Liverpool's Trent Alexander-Arnold, Andrew Robertson shine while Harry Kane disappoints
Liverpool won a disappointing Champions League against Tottenham 2-0 with an early goal from Mohammed Salah and a late goal from Divock Origi.
Champions League: 'Proud' Mauricio Pochettino hints he could stay at Tottenham Hotspur after final 2-0 final loss to Liverpool
Pochettino has said he wants clarity on Tottenham's ambitions before the start of next season and said on Saturday he would be holding talks with the club.