Arsenal welcome Sunderland, the only side still in the competition from outside the Premier League, to the Emirates.
City's record run in the competition came to an end at the London Stadium as the Hammers emerged 5-3 winners from a penalty shootout after both sides were guilty of missing plenty of chances in a 0-0 draw.
Kepa Arrizabalaga was the Chelsea hero as he made a string of late saves to deny Saints a place in the last eight as the game at Stamford Bridge ended 1-1 after 90 minutes.
United must rediscover their mojo quickly after a shock reverse in their Champions League opener against Young Boys, a League Cup exit to West Ham, and Saturday's defeat against Aston Villa.
David Moyes' men got a measure of revenge three days after their Premier League defeat to the 'Red Devils' as Manuel Lanzini's first half goal dumped United out in the third round.
Manchester United play West Ham for the second time in the space of four days when they meet in the third round of the League Cup.
The holders made the perfect start to that mission as Pep Guardiola was rewarded for fielding a strong attack featuring Kevin De Bruyne, Phil Foden, Raheem Sterling, Ferran Torres, and Riyad Mahrez at the Etihad Stadium.
Atlético Madrid try to end a two-game winless streak when they visit struggling Getafe in LaLiga.
Despite the presence of Ivory Coast forward Wilfried Zaha, Palace once again drew a blank as an 86th minute goal from Ashley Fletcher condemned Vieira to his second defeat.
Aymeric Laporte's header eight minutes from time finally ended Tottenham's resistance as their 13-year wait to win a trophy goes on.
To get into Wembley, fans had to take a lateral flow coronavirus test at a designated site in the 24 hours before the game and produce evidence of a negative result.
Given both clubs would gladly have turned their backs on the League Cup forever, it would be no surprise if there are protesters and dissenting voices among the 8,000 fans allowed into Wembley this weekend.
Tottenham have said that former player and club's academy coach Ryan Mason will take charge of the first team training on Monday.
Solskjaer said a key reason for United's poor home form is the red covering placed over seats which is making his players struggle to pick each other out for passes because their red shirts make them blend into the stadium background.
EFL Cup: Spectators attending Manchester City-Tottenham final required to produce negative COVID-19 test
A total crowd of 8,000 will be allowed to attend with the other 50 percent of tickets going to local residents near Wembley and National Health Service staff.
Champions League: Manchester City 'fresh and ready' to fight for quadruple, says midfielder Phil Foden
Foden struck in the 90th minute to give the Premier League leaders a hard-earned 2-1 win in the first leg at the Etihad Stadium on Tuesday, minutes after Marco Reus looked to have snatched a draw for the German side.
The council said each attendee has to return a negative lateral flow COVID-19 test 24 hours before attending the game and show proof to gain entry. They will also need to take a PCR home test after the event.
The FA Cup final is taking place two days before the government already plans to ease coronavirus restrictions to allow 10,000 fans but with social distancing at sports.
Harry Kane has made it clear he wants to see signs of progress with Tottenham before he will commit his long-term future to the club.