Inter, who beat Juventus 2-0 last month in Serie A, have it all to do to keep their hopes of lifting a first Italian Cup since 2011 alive.
Martinez and Romelu Lukaku proved decisive for the northeners, the strike duo being involved in five of Inter's goals.
FIFA World Cup 2022 Qualifiers: Brazil maintain perfect start with win over Uruguay; Argentina beat Peru
Victory in Montevideo left Brazil on top of South America's qualifying standings on 12 points with four wins from four games. Argentina are second on 10 points after beating Peru, with surprise team Ecuador third on nine points.
Serie A: Atalanta ease past Cagliari with a 5-2 victory; Inter Milan settle for 1-1 draw against Lazio
Inter Milan dropped their first points of the season as they drew 1-1 against Lazio in Serie A while Atalanta made it three wins out of three with a 5-2 victory over Cagliari.
Conte has made a habit of having an instant impact. He won league titles in his first season at Siena, Juventus and Chelsea, but believes his first year in Milan has seen a more gradual improvement.
Europa League: Romelu Lukaku, Lautaro Martinez score brace as Inter Milan thrash Shakhtar Donetsk to enter final
Conte is famous for his high demands of his players, but Lukaku believes the hard work Inter did before Italian football's return from a three-month shutdown due to the coronavirus pandemic is bearing fruit.
Lukaku swiftly developed a scintillating partnership with Lautaro Martínez and their goals helped Inter sustain a title challenge before eventually finishing second in Serie A, a point behind Juventus.
Serie A: Napoli shock Juventus on Maurizio Sarri's return; Cagliari dent Inter Milan’s title challenge
Serie A leader Juventus lost 2-1 at Napoli on Sunday in a miserable return for former coach Maurizio Sarri, and a poor day for its title challengers too.
Tokyo Olympics 2020: South American football teams to play pre-Olympic qualifying tournament without best players
For the last three Olympics, the South American Youth Championship was used as the Olympic qualifying event instead
Serie A: Zlatan Ibrahimovic scores in first start to set up victory for AC Milan; Inter held by Atalanta
Zlatan Ibrahimović is back. The 38-year-old scored in his first start back at AC Milan to end the Rossoneri’s goalless run and help them to a 2-0 win at Cagliari in Serie A on Saturday.
Serie A midseason review: Juventus, Inter Milan table toppers as they head into winter break; Lazio impress under Simone Inzaghi
Juventus and Inter headed into the winter break level on 42 points at the top of the table.
Champions League: Barcelona's 17-year-old Ansu Fati becomes youngest scorer in competition in 2-1 win over Inter Milan
Inter striker Lautaro Martinez had the ball in the net twice after the break, only for both goals to be disallowed for offside, before Fati smashed in a sublime finish in the final five minutes
Serie A: Ronaldo rescues point for Juventus against Sassuolo; Lautaro Martinez's brace helps Inter Milan reach top
Juventus needed Cristiano Ronaldo’s penalty to secure a point against Sassuolo before Inter Milan beat Spal 2-1 to move a point above the Bianconeri in the Serie A table.
Champions League: Inter Milan's Romelu Lukaku says he was target of racist chants by Slavia Prague fans
Inter Milan forward Romelu Lukaku says he was targeted with racist chants by Slavia Prague fans during a Champions League match and wants UEFA to take action.
Borussia Dortmund and their under-fire coach Lucien Favre hope to maintain the 'feel-good' factor from back-to-back wins as they chase Champions League revenge at home to Inter Milan on Tuesday
Champions League: Borussia Dortmund look to maintain 'element of joy' against Inter Milan after back-to-back Bundesliga victories
Dortmund must repeat the rock-solid defending in their draw at home to Barcelona in September to contain Inter's attack and the win over Inter suggests confidence is high
Serie A: Inter beat Sassuolo to keep pace with Juventus; Stefano Pioli's AC Milan debut ends in 2-2 draw against Lecce
Inter Milan survived a late Sassuolo scare and a bizarre intervention by a parachutist to win 4-3 and keep in touch with leaders Juventus in Serie A on Sunday as Stefano Pioli's first game in charge of AC Milan ended in a 2-2 draw against lowly Lecce.
Serie A: Romelu Lukaku scores on Inter Milan debut as Antonio Conte starts San Siro reign with thumping win over Lecce
Belgian forward Romelu Lukaku scored on his Inter Milan debut as new coach Antonio Conte's reign got off to a perfect start with a 4-0 win over Lecce.
Copa America 2019: Amid struggling defence, Argentina's quest for identity continues despite 2-0 win over Venezuela
Argentina have progressed to the last four after a disastrous defeat to Carlos Queiroz’s Colombia, but that mini recovery hasn’t concealed the profound identity crisis engulfing the team.