Formula 1 2020: Racing Point's Sergio Perez bids tearful farewell after engine failure wrecks Abu Dhabi GP
"It is sad to be leaving the team this way," said Perez, who said he retained hopes of staying in Formula One with Red Bull, if they chose him as a replacement for Alex Albon.
On his final lap, slowing down round the Yas Marina Circuit, Vettel surprised many by singing an Italian song about Ferrari on the team radio system.
Perez, who has been at Racing Point, previously known as Force India, since 2014, is to be replaced next year, when the team is re-branded as Aston Martin, by four-time world champion Sebastian Vettel.
The Racing Point driver finished 10.5 seconds ahead of Renault's Esteban Ocon and 11.9 clear of teammate Lance Stroll.
Formula 1 2020: Red Bull sporting director Jonathan Wheatley to miss Bahrain GP after testing positive for COVID-19
The vastly-experienced key pit-wall decision-maker returned a positive test during mandatory pre-race tests and will be isolation for 10-days in line with the sport’s protocols and public health guidelines.
Defending six-time champion Hamilton, who bids to capture a record-equalling seventh world title in Sunday's race, was only sixth in qualifying with his teammate Valtteri Bottas in ninth.
For Racing Point's Lance Stroll, this was the first pole position of his Formula One career. His teammate Sergio Perez was third.
French driver Pierre Gasly's car caught fire on Friday while there was a crash between Red Bull's Max Verstappen and Lance Stroll's Racing Point car.
Formula 1 has revised COVID-19 testing protocols after Lance Stroll case, says Racing Point boss Otmar Szafnauer
Canadian Stroll, 21, left the Eifel event early on Sunday, flying home to Switzerland, where he returned a positive test result on Monday.
Lewis Hamilton and Mercedes seek to continue their record-making progress as Formula One escapes in search of some autumnal sunshine at this weekend's Portuguese Grand Prix.
Formula 1 2020: Racing Point driver Lance Stroll intent on competing at Portuguese GP following week of self-isolation
In a post on Instagram, Stroll said he spent 10 days at home in self-isolation with mild symptoms and returned a negative test on Monday.
"I don’t think we need to be in on Fridays," said Lewis Hamilton.
Hamilton briefly sat atop the time charts, but his Mercedes teammate Bottas sped through seconds later with an unbeatable time, fastest in all three sectors of the Nürburgring track.
It was not made clear if Stroll had tested positive for COVID-19. But Stroll's teammate Sergio Perez after returning from Mexico and testing positive for the coronavirus ahead of the British Grand Prix in July.
Sergio Perez will be replaced next season at Racing Point by Sebastian Vettel.
Formula 1 2020: Pierre Gasly races to stunning victory at Italian GP as Lewis Hamilton handed penalty
Pierre Gasly finished 0.415 seconds ahead of McLaren driver Carlos Sainz and 3.358 ahead of Racing Point's Lance Stroll on a surreal-looking podium.
Formula 1 2020: Eight drivers summoned by stewards over Lewis Hamilton near-miss during Italian GP practice
As a result of the incident, when Hamilton changed direction at around 300 kph, he was summoned along with Nicholas Latifi, Romain Grosjean, Sergio Perez, Pierre Gasly, Lance Stroll, Alex Albon and Carlos Sainz to explain what happened.
Speaking ahead of this weekend's Belgian Grand Prix, Perez told reporters that he believed his contract will be honoured and that no other driver could have extracted more speed or performance from his car this year.
It was the world championship leader and six-time champion's fifth win in Spain and his fourth in consecutive years, extending his record run of finishes in the points to 39.
Formula 1 2020: Lance Stroll quickest at 2nd British Grand Prix practice; Sebastian Vettel struggles
Lance Stroll's unexpected teammate Nico Hulkenberg was seventh after filling in at the last minute for Sergio Perez.