Mauricio Pochettino's men had drawn four of their five previous league games before second-placed Nice closed to within eight points by beating Nantes
Mbappe scored a hat-trick as PSG overcame their COVDI-19 crisis and a drone-related interruption to ease into the French Cup last 16 on Monday with a 4-0 win over fourth-division Vannes.
The World Cup winner's PSG deal ends in June, with the 23-year-old now free to sign a pre-contract agreement with another club
In October Mbappe confirmed he had told Paris Saint-Germain last July he wanted to leave the club.
Mbappe said it was important not to wear players out, but that maintaining the competition's beauty was his key motive.
Kylian Mbappe reached a century of Ligue 1 goals for Paris Saint-Germain with a brace in Sunday's 2-0 win over his old club Monaco at the Parc des Princes.
Diego Simeone's Atletico needed to beat Porto in Portugal to advance to the knockout phase and they duly triumphed 3-1 in a game which featured three red cards.
Robert Lewandowski, Lionel Messi and Cristiano Ronaldo among 11-man shortlist for Best FIFA Men's Player award
Robert Lewandowski is in the running to retain his Best FIFA Men's Player award after he was named Monday on an 11-man shortlist alongside Karim Benzema and Jorginho.
Lionel Messi struck his first goal in Ligue 1 on Saturday as Paris Saint-Germain overcame a red card for goalkeeper Keylor Navas to defeat Nantes 3-1.
FIFA World Cup 2022 Qualifiers: Four-goal Kylian Mbappe fires France into finals, Belgium also qualify
The French will be joined at the finals by neighbours Belgium as the world's top-ranked team saw off Estonia 3-1 in Brussels to ensure top spot in Group E
PSG moved 10 points clear of second-place Lens, who thrashed Troyes 4-0 on Friday. Nice, who host Montpellier on Sunday, are another point further back.
Mbappe has scored five Ligue 1 goals so far this season as PSG threaten to run away with the title.
Messi and Neymar missed PSG's match as they played in World Qualifiers recently.
Mbappe struck with 10 minutes remaining to win the title for world champions France after Karim Benzema had levelled just two minutes after Mikel Oyarzabal put Spain into a 64th-minute lead.
Down by two goals at half-time on Thursday following quickfire strikes from Yannick Carrasco and Romelu Lukaku, a demoralising run of results and performances appeared set to continue in Turin.
AC Milan full-back Hernandez netted his first France goal in the 90th minute of his second international appearance after France had come back from 2-0 down at half-time at the Allianz Stadium in Turin through strikes from Karim Benzema and Kylian Mbappe.
LaLiga: Florentino Perez says comments about Kylian Mbappe's potential move to Madrid 'incorrectly interpreted'
On Monday, World Cup winner Mbappe said he had told Paris Saint-Germain he wanted to leave the French capital last July, a month before Madrid bid 180 million euros ($209 million) for him — an offer PSG turned down.
Kylian Mbappe revealed he asked to go in July and hoped to leave with a good deal and respect on all sides. Reports that his request was in the last week of August made him sound like a thief, Mbappe said.
Messi lined up alongside Neymar, Mbappe and Angel Di Maria for just the second match, making only his second league start for PSG after missing two Ligue 1 games with a knee injury.
Here's all you need to know about the Matchday 2 of UEFA Champions League on Tuesday.