The loss in Seville was Germany's heaviest defeat since 1931 and ended the team's chances of qualifying for the Nations League final four. Loew said after the game that he had no plans to resign after 14 years in charge.
Spain put all the criticism and the pressure to rest on Tuesday after routing four-time World Cup champion Germany 6-0.
Ferran Torres scored a hat-trick with Loew's Germany offering little resistance as they slumped to their heaviest defeat since losing 6-0 against Austria in 1931.
German midfielder Sebastian Rudy and Algerian forward Ishak Belfodil, plus a member of their coaching staff, have tested positive for COVID-19, Hoffenheim said on Wednesday.
"We as players should not complain, even if we have reached our limits — we're allowed to play, in contrast to many others (sports)," Neuer said.
Nations League: Germany held for a draw by Switzerland as pressure mounts on Joachim Loew; Ukraine stuns Spain
Germany have drawn four of their last five games — surrendering the lead on three occasions— to leave them second in their Nations League group behind Spain.
Loew has a contract until 2022, but his popularity — which peaked when Germany won the 2014 World Cup — crashed after the 2018 finals in Russia, where the Germans failed to get out of their group.
UEFA Nations League: Mikel Oyarzabal's strike helps Spain edge Switzerland; Germany scrape past Ukraine
At the Estadio Alfredo Di Stefano in Madrid, usually home of Real Madrid's second string side, Real Sociedad striker Oyarzabal struck in the 14th minute.
International friendlies: Irritated Joachim Loew looks to fix Germany's leadership woes after Turkey draw
In his post-match analysis after the draw with Turkey, Loew was "disappointed and pissed off" by his team's inability to control the game, finish chances and keep hold of possession.
UEFA Nations League: International football returns after lengthy absence with Germany vs Spain clash
Six rounds of Nations League matches will take place in total between September and November, with the top four nations coming together for the finals.
“I don’t need any more applause,” André Schürrle told a German magazine after being released from his contract with Borussia Dortmund on Wednesday.
With a rebuilt team, Germany faces a tough test at the European Championship with group games against France and Portugal, the reigning world and European champions respectively
Germany have secured qualification for Euro 2020, but coach Joachim Loew is running out of time to mould his fledgling team into title contenders before next June's finals.
Euro 2020 Qualifiers: Germany team director Oliver Bierhoff hopes display of strength against Belarus will boost ticket sales
The Germans and Dutch are level on 15 points with the top two teams going through, so Germany can wrap up Euro 2020 qualification on Saturday for next June's finals against Belarus by bettering third-placed Northern Ireland's result against Holland
UEFA Euro Qualifiers 2020: Germany coach Joachim Loew rules out recalling Mats Hummels for games against Belarus, Northern Ireland
The 30-year-old Hummels has rebooted his career since leaving Bayern Munich in the summer to return to Borussia Dortmund, the club he represented 225 times between 2009 and 2016, having been told by Loew in March that his Germany days are over.
Bayern Munich's Uli Hoeness threatens German national team with boycott if Manuel Neuer loses No 1 goalkeeper spot
Bayern Munich president Uli Hoeness has threatened to deprive the German national side of Bayern players if Manuel Neuer loses the number one goalkeeper spot to Marc-Andre Ter Stegen.
FIFA rankings: Germany's slide continues as 2014 World Cup winners drop to World No 16; Belgium retain top spot
As the 11th highest ranked European team, 2014 World Cup winner Germany risk being in the second-seeded pot and getting a tougher opponent when qualifying groups for the 2022 World Cup are drawn, likely next year.
Euro 2020 Qualifiers: Midfielder Ilkay Gundogan set to miss Germany's key fixture against Northern Ireland with flu
28-year-old Ilkay Gundogan left the team German hotel in Belfast on Sunday to return to Manchester and misses the top-of-the-table clash at Windsor Park
Euro 2020 Qualifiers: Whirlwind comeback gives Netherlands 4-2 win over Germany, Belgium cruise past San Marino
Netherlands scored four goals in just 32 minutes to take the game from 2-2 to 4-2 in the closing stages of the Euro 2020 Qualifiers.
Former Germany and Real Madrid footballer Christoph Metzelder under investigation for sharing child pornography
Authorities have raided Metzelder's home and offices in Duesseldorf, and seized a laptop and a mobile phone.