De Rossi was sent off with his side leading 1-0 after 69 minutes for hitting Lapadula in the face and the Genoa striker scored the resulting penalty for a 1-1 draw.
Serie A: AS Roma host rivals Lazio in high-stakes derby; league leaders Napoli face under-pressure AC Milan
Italy's stunned internationals return to the mundane setting of Serie A this weekend days after their star status in world football imploded with a shocking World Cup exit.
FIFA World Cup 2018 qualifiers: Italy coach Gian Piero Ventura refuses to resign despite not qualifying for finals
Ventura was widely criticized for poor tactical decisions before and after Sweden's 1-0 aggregate win over the Azzurri.
FIFA World Cup 2018 qualifiers: Italy's failure to reach finals calls for reinvention of their youth structure
There is something inherently wrong with the Italy's system. Gifted young players are not emerging in sufficient quantities, or not being developed. Germany, France and England have all undergone awkward reassessments of their youth structures; Italy must undergo a similar reboot.
Gianluigi Buffon had solidly represented the Azzurri for the past 20 years, earning a record 175 caps, but this time not even he could lift a second-rate Italy side.
FIFA World Cup 2018 qualifiers: Gianluigi Buffon says Italy must not panic despite staring at disaster
Captain Buffon – bidding to reach a record sixth World Cup finals in Russia – is one of the last survivors of Italy's golden generation of 2006 World Cup winners.
FIFA World Cup 2018 qualifiers: Italy on brink of elimination after Sweden clinch win in play-off's first leg
Gian Piero Ventura's Italy will need to respond in Monday's return leg at the San Siro in Milan to avoid becoming only the second Azzurri outfit to fail to reach the finals.
FIFA World Cup 2018 qualifiers: Italy's Daniele De Rossi relieved about Zlatan Ibrahimovic's absence in play-off
"I'd never want Ibra against me, not even at 40 years and with a broken leg," said De Rossi.
FIFA 2018 World Cup qualifiers: Italy failing to qualify would be catastrophic, says coach Giampiero Ventura
"I'm not thinking about the play-offs, we need to think about the next two matches and then based on who we meet we'll weigh things up," said Ventura.
Serie A: Daniele De Rossi reveals he wouldn't be at AS Roma if suitable offer had come from Europe or MLS
De Rossi, who took over as captain after Totti's departure, had said at the time that not signing a new contract would have been too "big a blow" for the club.
Italy were outclassed by Spain in a demoralising 3-0 World Cup qualifying defeat in Madrid which leaves the four-time champions facing a precarious play-off in November to reach Russia.
Totti’s creative genius was nurtured by Fabio Capello as he started to contribute more goals and assists than ever before. His ability to pick out a pass made him outstanding.
By the end of a valuable win that secured Roma's place in next season's Champions League, Totti experienced a send-off that saw almost the entire stadium shed tears.
Daniele De Rossi's late penalty rescued a point for Italy against Spain in a heavyweight World Cup qualifier on Thursday, as Wales played out an entertaining draw in Austria.
AS Roma suffered a major European humiliation on Tuesday, when they had two players sent off, losing 3-0 at home to Porto and missed out on the Champions League group stage
Injury-hit midfielder Daniele De Rossi is virtually certain to miss Italy's Euro 2016 quarter-final clash with world champions Germany on Saturday.
Joachim Loew insists the world champions have no Italian complex as Germany attempt to break their Azzurri curse in Saturday's Euro 2016 quarter-final.
Italy are facing a serious selection headache in midfield ahead of their Euro 2016 quarter-final against Germany after Thiago Motta incurred a suspension.
The Republic of Ireland can take inspiration from one of the finest moments in their footballing history as they face Italy in Euro 2016 on Wednesday.
If Conte's strategy works for Italy, retrospective wisdom would point to experience doing the job; if it doesn't, an ageing squad would be shown the door