Two-time MVP winner Antetokounmpo hit 14-of-21 shots from the floor and Khris Middleton finished with 25 points for the host Bucks, who have won seven of their last eight games.
NBA: Lakers rout OKC for franchise-record 7-0 road start; Trail Blazers tie franchise record 23 3-pointers
The defending champions Lakers have won four straight to improve to an NBA-best 10-3. They surpassed the 1985-86 squad with the 7-0 road start
NBA also said it would meet with the National Basketball Players Association about possible modifications in the joint safety protocols.
The 76ers came in at 7-1 and off their best performance of the season, when they shot an NBA season-high 61.7% in a 141-136 victory over Washington
The reigning two-time MVP Giannis Antetokounmpo scored 30 points by halftime, shot 17 of 24 from the floor overall and finished with nine rebounds.
Stephen Curry had the highest-scoring game in the NBA this season, finishing 18 for 31 and 8 of 16 on 3-pointers after beginning with a 21-point first quarter.
The Lakers closed with a 9-0 run for their second victory over the Spurs in three days.
In Charlotte, Gordon Hayward scored 28 points as the Hornets cooled off red-hot Brooklyn, handing the Nets their first defeat of the season 106-104.
NBA: Kyrie Irving, Duncan Robinson spark routs with record 3-point shows, LeBron James becomes No. 2 Christmas scorer
Irving scored 37 points, hitting 7-of-10 3-point attempts in his return to Boston, as the Nets ripped his former Celtics teammates 123-95.
Antetokounmpo, who last week signed a five-year contract extension reportedly worth a record $228 million, led Milwaukee with 35 points, 13 rebounds, two assists and two blocked shots.
NBA season preview: From Lakers getting stronger to Bucks winning free agency, biggest talking points
After the most protracted, and yet abbreviated, season of the NBA comes the shortest season of the league. Here are the biggest talking points:
Franchises are fine-tuning their rosters as veterans work on their roles and rookies seek to show they can contribute with the new NBA season less than two weeks away.
Fox's numbers have improved in each of his three NBA seasons. He averaged 11.6 points as a rookie, then 17.3 points two seasons ago and finally 21.1 points last season for the Kings. His field goal percentage has also risen in each of the last two seasons.
Porzingis signed a $158 million, five-year max contract with Dallas in July 2019.
NBA: Jamal Murray scores 50 points, Denver Nuggets force Game 7 with Utah Jazz; Los Angeles Clippers eliminate Dallas Mavericks
Denver Nuggets and Utah Jazz will go at it one more time on Tuesday night, with the winner advancing to face the Los Angeles Clippers.
The 21-year old Slovenian phenom, who was playing with a tender ankle and missing his offensive sidekick Kristaps Porzingis, finished with 43 points, 17 rebounds and 13 assists to level the first-round NBA Western Conference playoff series at two games each.
NBA: Dallas Mavericks' Luka Doncic insists left ankle injury is just 'a little sprain', 'not that bad'
Doncic twisted the ankle and hit the court, clearly in pain. He hopped to the sideline and was helped to the locker room, returning in the fourth quarter with the ankle heavily taped.
Kawhi Leonard had 29 points and 12 rebounds, and the Clippers got a big boost from the ejection of Kristaps Porzingis to beat the Dallas Mavericks 118-110 in Game 1 of their Western Conference playoff
NBA: For first time in 23 seasons, San Antonio Spurs miss playoffs; Portland Trail Blazers, Memphis Grizzlies advance to play-in tournament
Spurs were officially ousted when Memphis beat Milwaukee, and Phoenix completed an undefeated eight-game run in the NBA's restart bubble with a victory over Dallas.
The full list of NBA Playoff matchups won't be known until at least Saturday, when the West play-in series begins with Portland, Memphis, Phoenix and San Antonio bidding for those two spots.