After their trip to Uruguay, Argentina, unbeaten in 25 matches, host Brazil next week and victories in both could be enough to book their ticket to Qatar.
FIFA World Cup Qualifying: Lautaro Martinez extends Argentina's run to 25 unbeaten, Brazil thrash Uruguay
Brazil top the single South American qualifying group by six points from Argentina, who have a nine point gap to those that could deny them a berth at Qatar 2022.
Goals from Rodrigo De Paul and Lautaro Martinez rounded off a successful night for Lionel Scaloni's team in Buenos Aires as they maintained their unbeaten start to the qualification campaign
Lionel Messi leaves Barcelona as their all-time top scorer with 672 goals in 778 appearances. His goal tally is a record for one club.
The victory sent Argentina joint top of Group A with Chile on four points while Uruguay remain pointless.
Catch the live score and updates from Match 23 of the FIFA World Cup between Argentina and Croatia