The win continues Inter's sparkling form, with eight wins from their last eight matches in Serie A, which they lead by a point from city rivals AC Milan.
Neymar will return for Brazil and Alexis Sánchez has recovered from a calf muscle injury ahead of the encounter at the Nilton Santos Stadium in Rio de Janeiro.
Chile's national team said in a statement on Saturday that 32-year-old Sánchez felt muscular soreness in a calf after a training session. They did not give more details.
The draw leaves Argentina a point behind Brazil, the only remaining side with a perfect qualifying record, who host Ecuador on Friday.
Serie A: Five-goal Inter Milan celebrate title with record 14th consecutive home win; Napoli move second
Since losing against Sampdoria, Inter Milan have gone 18 games without defeat and have now won 14 games in a row at home for the first time.
Romelu Lukaku had a role in both the goals by his former Manchester United teammate to give Antonio Conte's side a sixth consecutive league win.
Serie A: Romelu Lukaku scores inside first minute as Inter Milan pull seven points clear; AC Milan beat Roma
Atalanta shook off their Champions League defeat to Real Madrid midweek with a 2-0 win at Sampdoria to move up to fourth.
Second-placed Inter stay one point behind Serie A leaders AC Milan who host champions Juventus later on Wednesday.
Inter played with the ferocity coach Antonio Conte had been demanding and Sassuolo barely had a sight of goal apart from a curled effort from Filip Đuričić that hit the outside of the right post.
Inter Milan forward Alexis Sanchez says he wanted to leave Manchester United right after first training session
Sanchez has explained his side of the story in a video on Instagram, admitting he immediately had a bad feeling about his switch to United.
Sanchez pulled up injured during his side's 2-1 quarter-final win over Bayer Leverkusen in Germany, and looks doubtful for Monday's semi-final against the Ukrainian side.
Alexis Sanchez has been on loan with Inter Milan since August last year after he struggled for playing time at Manchester United.
Inter dominated from the start but took until eight minutes from halftime to break the deadlock when Candreva fired home following a pinpoint assist from Sánchez.
Premier League: All clubs spend lot of money, Manchester City aren't the only ones, says Pep Guardiola
For Guardiola, who won back-to-back titles in 2018 and 2019, City are by no means unusual when it comes to spending big on players.
Inter Milan needed to win to hold off hard-charging Atalanta in the race for third and took the lead in the fifth minute when Young was left unmarked to volley in Sánchez’s cross.
Premier League: Manchester United boss Ole Gunnar Solskjaer says full-back Ashley Young nearing transfer to Inter Milan
Solskjaer said that Young will be 35 soon and if he gets a two-year contract elsewhere, it was up to him to take that as United weren't ready to offer him that
Premier League: Manchester United boss Ole Gunnar Solskjaer says Mason Greenwood should focus on improving, senior England debut will happen in time
Greenwood's eye-catching performances have led to calls for him to be handed his senior England debut but Solskjaer said the youngster first needs to focus on improving himself
Serie A: Inter Milan striker Alexis Sanchez undergoes surgery after picking up ankle injury during Chile's friendly against Colombia
Sanchez hobbled off in the 88th minute of a goalless draw in the friendly against Colombia in Alicante on Saturday.
Alexis Sanchez picks up ankle injury in Chile's goalless draw against Colombia, faces prospect of surgery
Chile striker Alexis Sanchez may need surgery on his ankle after picking up an injury in their 0-0 draw with Colombia last week, his club side Inter Milan have said.
Serie A: Inter Milan's Alexis Sanchez could be out for three months after suffering ankle injury on international duty for Chile
Chile play Guinea on Tuesday in another friendly but Rueda was worried that Sanchez might have to miss the start of South American World Cup qualifying in March